-transparent.png){kind=logo}
To detect the minimal residual disease (MRD) in acute promyelocytic leukaemia patients treated with all-trans retinoic acid, we compared the sensitivity of metaphase fluorescence in situ hybridization (FISH) with conventional analysis of G-banded metaphases. 5 out of 6 patients studied at diagnosis showed the t(15;17) translocation. 4 out of 5 patients carrying t(15;17) achieved complete remission and conventional cytogenetic conversion. In 3 cases the whole chromosome painting (WCP) probe 17 discovered one normal chromosome 17 and two fragments indicative of t(15;17) persistence. The FISH-WCP technique seems to be highly sensitive and recommendable in monitoring leukaemias with specific chromosome rearrangements.
P Temperani, and
P Vaccari, and
F Giacobbi, and
G Gandini, and
M G Ferrari, and
G Emilia
December 1993,
Seminars in cancer biology,
P Temperani, and
P Vaccari, and
F Giacobbi, and
G Gandini, and
M G Ferrari, and
G Emilia
March 1997,
British journal of haematology,
P Temperani, and
P Vaccari, and
F Giacobbi, and
G Gandini, and
M G Ferrari, and
G Emilia
February 2000,
Leukemia,
P Temperani, and
P Vaccari, and
F Giacobbi, and
G Gandini, and
M G Ferrari, and
G Emilia
February 2013,
Pathology,
P Temperani, and
P Vaccari, and
F Giacobbi, and
G Gandini, and
M G Ferrari, and
G Emilia
October 1992,
Bailliere's clinical haematology,
P Temperani, and
P Vaccari, and
F Giacobbi, and
G Gandini, and
M G Ferrari, and
G Emilia
March 2002,
Best practice & research. Clinical haematology,
P Temperani, and
P Vaccari, and
F Giacobbi, and
G Gandini, and
M G Ferrari, and
G Emilia
January 1985,
Nature,
P Temperani, and
P Vaccari, and
F Giacobbi, and
G Gandini, and
M G Ferrari, and
G Emilia
October 1995,
Annals of oncology : official journal of the European Society for Medical Oncology,
P Temperani, and
P Vaccari, and
F Giacobbi, and
G Gandini, and
M G Ferrari, and
G Emilia
December 1996,
British journal of haematology,
P Temperani, and
P Vaccari, and
F Giacobbi, and
G Gandini, and
M G Ferrari, and
G Emilia
March 2014,
Best practice & research. Clinical haematology,
