-transparent.png){kind=logo}
We have identified succinic semialdehyde dehydrogenase protein in rat and human neural and nonneural tissues. Tissue localization was determined by enzymatic assay and by western immunoblotting using polyclonal antibodies raised in rabbit against the purified rat brain protein. Although brain shows the highest level of succinic semialdehyde dehydrogenase activity, substantial amounts of enzyme activity occur in mammalian liver, pituitary, heart, and ovary. We further demonstrate the absence of succinic semialdehyde dehydrogenase enzyme activity and protein in brain, liver, and kidney tissue samples from an individual affected with succinic semialdehyde dehydrogenase deficiency, thereby verifying the specificity of our antibodies.
K L Chambliss, and
Y A Zhang, and
E Rossier, and
B Vollmer, and
K M Gibson
August 1964,
Biochemical pharmacology,
K L Chambliss, and
Y A Zhang, and
E Rossier, and
B Vollmer, and
K M Gibson
January 1979,
Advances in experimental medicine and biology,
K L Chambliss, and
Y A Zhang, and
E Rossier, and
B Vollmer, and
K M Gibson
September 1984,
Journal of neurogenetics,
K L Chambliss, and
Y A Zhang, and
E Rossier, and
B Vollmer, and
K M Gibson
September 2011,
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,
K L Chambliss, and
Y A Zhang, and
E Rossier, and
B Vollmer, and
K M Gibson
January 1977,
Biochimie,
K L Chambliss, and
Y A Zhang, and
E Rossier, and
B Vollmer, and
K M Gibson
June 1981,
European journal of biochemistry,
K L Chambliss, and
Y A Zhang, and
E Rossier, and
B Vollmer, and
K M Gibson
April 1985,
Journal of neurogenetics,
K L Chambliss, and
Y A Zhang, and
E Rossier, and
B Vollmer, and
K M Gibson
January 1997,
Advances in experimental medicine and biology,
K L Chambliss, and
Y A Zhang, and
E Rossier, and
B Vollmer, and
K M Gibson
December 1983,
Analytical biochemistry,
K L Chambliss, and
Y A Zhang, and
E Rossier, and
B Vollmer, and
K M Gibson
April 2010,
Pediatric neurology,
