Detection of loco-regional recurrence after breast-conserving surgery and radiotherapy. 1995

S T Hussian, and G P Gui, and K S Lee, and P N Plowman, and O J Gilmore, and W H Allum
Breast Unit, St Bartholomew's Hospital, West Smithfield, London, UK.

This study evaluates the incidence, pattern and mode of detection of loco-regional recurrence (LRR) after conservative surgery for invasive breast cancer. Over an 11-year period, 354 patients were treated with wide local excision, axillary sampling and radiotherapy to the remaining breast. LRR occurred in 33 patients (9.3%). Local recurrence (LR) in the conserved breast occurred in 73% (24/33)of the patients while regional recurrence (RR) accounted for 9% (3/33). There were 6 (18%) patients with both local and regional recurrence. Recurrence was detected clinically in 85% (28/33) and mammographically in 15% (5/33) Of those patients who have had their recurrences detected clinically 61% (17/28) have died. None of the 5 patients with mammographic recurrences have died. Patients who develop LR after conservative surgery do better if the lesion is detected mammographically compared with those detected clinically (P < 0.03, Fisher's exact test). Mammography, in addition to regular clinical review, is an important aspect of the follow-up protocol after breast conserving surgery.

UI MeSH Term Description Entries
D009364 Neoplasm Recurrence, Local The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site. Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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