Biomaterial Database

Modulation of the escape response by [D-Ala2]Met-enkephalin in the crab Chasmagnathus. 1995

A M Godoy, and H Maldonado

Laboratorio de Fisiología del Comportamiento Animal, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaira, Buenos Aires, Argentina.

The synthetic opioid analog [D-Ala2]Met-enkephalin (DAME) significantly reduces the escape response to a danger stimulus in the crab Chasmagnathus granulatus when administered within the dose range 0.01-1.0 micrograms/g. There is no reduction with lower or higher doses, thus suggesting a U-shaped dose-response curve. A 0.1-microgram/g dose of naloxone has no effect per se on the response, but when it is administered together with DAME, it completely blocks the decremental effect of this drug and an escape response generally higher than that of control is observed. An explanation for these results in terms of a possible dual action of DAME is offered. In addition, we present evidence for different degrees of opiate sensitivity among crabs of the same population in relation to their different degrees of reactivity to the visual danger stimulus.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010865	Pilot Projects	Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.	Pilot Studies,Pilot Study,Pilot Project,Project, Pilot,Projects, Pilot,Studies, Pilot,Study, Pilot
D003386	Brachyura	An infraorder of chiefly marine, largely carnivorous CRUSTACEA, in the order DECAPODA, including the genera Cancer, Uca, and Callinectes.	Blue Crab,Callinectes sapidus,Carcinus maenas,Crab, Blue,Crab, Common Shore,Crab, Green,Crabs, Short-Tailed,Crabs, True,Green Crab,Uca,Common Shore Crab,European Shore Crab,Blue Crabs,Brachyuras,Carcinus maena,Common Shore Crabs,Crab, European Shore,Crab, Short-Tailed,Crab, True,Crabs, Blue,Crabs, Common Shore,Crabs, Green,Crabs, Short Tailed,Green Crabs,Shore Crab, Common,Shore Crab, European,Shore Crabs, Common,Short-Tailed Crab,Short-Tailed Crabs,True Crab,True Crabs,Ucas,maenas, Carcinus
D004744	Enkephalin, Methionine	One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.	Methionine Enkephalin,5-Methionine Enkephalin,Met(5)-Enkephalin,Met-Enkephalin,5 Methionine Enkephalin,Enkephalin, 5-Methionine,Met Enkephalin
D004924	Escape Reaction	Innate response elicited by sensory stimuli associated with a threatening situation, or actual confrontation with an enemy.	Flight Reaction,Escape Reactions,Flight Reactions,Reaction, Escape,Reaction, Flight,Reactions, Escape,Reactions, Flight
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia