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Ammonia toxicity and the protective effect of arginine thereon were investigated in rats after single and repeated doses of galactosamine. Urea cycle enzymes and ornithine-oxo-acid transaminase activities were measured in rat liver homogenates. Ammonium acetate proved to be less toxic in rats treated with single or repeated doses of galactosamine than in untreated animals. Urea cycle enzyme activities of galactosamine-treated rats were clearly lowered. The protective effect of arginine against lethal ammonia intoxication was found in animals that had been treated with galactosamine as well as in untreated rats. Since the toxicity of ammonium acetate is lower in rats with galactosamine hepatitis, in which the activities of the liver urea cycle enzymes are reduced, it seems likely that ammonia detoxication in galactosamine-poisoned rat liver partly bypasses the urea cycle.
H J Senn, and
K P Maier, and
G Hoppe-Seyler, and
W Gerok
January 1981,
Journal de pharmacologie,
H J Senn, and
K P Maier, and
G Hoppe-Seyler, and
W Gerok
February 1980,
The Japanese journal of antibiotics,
H J Senn, and
K P Maier, and
G Hoppe-Seyler, and
W Gerok
February 1980,
The Journal of toxicological sciences,
H J Senn, and
K P Maier, and
G Hoppe-Seyler, and
W Gerok
August 1975,
The Japanese journal of antibiotics,
H J Senn, and
K P Maier, and
G Hoppe-Seyler, and
W Gerok
February 1982,
The Japanese journal of antibiotics,
H J Senn, and
K P Maier, and
G Hoppe-Seyler, and
W Gerok
August 1976,
The Japanese journal of antibiotics,
H J Senn, and
K P Maier, and
G Hoppe-Seyler, and
W Gerok
June 1976,
The Japanese journal of antibiotics,
H J Senn, and
K P Maier, and
G Hoppe-Seyler, and
W Gerok
June 1977,
The Japanese journal of antibiotics,
H J Senn, and
K P Maier, and
G Hoppe-Seyler, and
W Gerok
January 1978,
Arzneimittel-Forschung,
H J Senn, and
K P Maier, and
G Hoppe-Seyler, and
W Gerok
April 1975,
The Japanese journal of antibiotics,
