-transparent.png){kind=logo}
OBJECTIVE This study examines the hypothesis that neutrophils impair splanchnic blood flow during resuscitation from hemorrhage by inhibiting the release of the compensatory vasodilator PGI2 from the bowel. BACKGROUND Resuscitation from hemorrhagic shock is associated with neutrophil infiltration into the intestine, reduced splanchnic perfusion, and reduced release of PGI2 from the intestine. METHODS Sprague-Dawley rats received either vinblastine (VIN) to deplete circulating neutrophils or normal saline (NS). These animals then underwent either hemorrhage and resuscitation (SK + R) or sham operation (SHAM). Superior mesenteric artery flow and splanchnic 6-keto PGF1a (metabolite of PGI2) release were measured. RESULTS Superior mesenteric artery blood flow was significantly greater in VIN-treated animals sustaining SK + R than in those treated with NS (p < 0.05). Neutrophil depletion preserved 6-keto PGF1a release after SK + R, whereas 6-keto PGF1a release in the NS-treated, SK + R group was significantly reduced (p < 0.05). CONCLUSIONS These data are compatible with the hypothesis that neutrophils may influence splanchnic perfusion after SK + R by inhibiting splanchnic PGI2 release.
R H Turnage, and
K M Kadesky, and
T Rogers, and
R Hernandez, and
L Bartula, and
S I Myers
January 1964,
Surgical forum,
R H Turnage, and
K M Kadesky, and
T Rogers, and
R Hernandez, and
L Bartula, and
S I Myers
February 1965,
The American journal of physiology,
R H Turnage, and
K M Kadesky, and
T Rogers, and
R Hernandez, and
L Bartula, and
S I Myers
January 1970,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
R H Turnage, and
K M Kadesky, and
T Rogers, and
R Hernandez, and
L Bartula, and
S I Myers
June 1994,
Journal of applied physiology (Bethesda, Md. : 1985),
R H Turnage, and
K M Kadesky, and
T Rogers, and
R Hernandez, and
L Bartula, and
S I Myers
October 1991,
The Journal of surgical research,
R H Turnage, and
K M Kadesky, and
T Rogers, and
R Hernandez, and
L Bartula, and
S I Myers
February 1971,
American journal of surgery,
R H Turnage, and
K M Kadesky, and
T Rogers, and
R Hernandez, and
L Bartula, and
S I Myers
April 1981,
Archives of surgery (Chicago, Ill. : 1960),
R H Turnage, and
K M Kadesky, and
T Rogers, and
R Hernandez, and
L Bartula, and
S I Myers
October 1971,
Advances in experimental medicine and biology,
R H Turnage, and
K M Kadesky, and
T Rogers, and
R Hernandez, and
L Bartula, and
S I Myers
July 1971,
Annals of surgery,
R H Turnage, and
K M Kadesky, and
T Rogers, and
R Hernandez, and
L Bartula, and
S I Myers
December 1955,
Science (New York, N.Y.),
