BIOMAT Database Logo BIOMAT Database Logo

Dicloxacillin and flucloxacillin: pharmacokinetics, protein binding and serum bactericidal titers in healthy subjects after oral administration. 1995

B L Røder, and N Frimodt-Møller, and F Espersen, and S N Rasmussen
Div. of Preventive Microbiology, Statens Seruminstitut, Copenhagen, Denmark.

The pharmacokinetics of dicloxacillin and flucloxacillin were studied in 12 healthy volunteers after oral administration. The participants received a single dose of either dicloxacillin (0.5 g, 0.75 g or 1.0 g) or flucloxacillin (0.75 g) in a cross-over fashion. Antibiotic concentrations were determined in serum and urine by bioassay and followed for 8 and 24 h, respectively. The three dicloxacillin dosages showed no significant differences for the serum elimination half-lives (t1/2 beta, median: 72 min). Comparing 0.75 g flucloxacillin with the same dose of dicloxacillin, no significant differences between the values of Cmax, t1/2 beta and AUC were found. Protein binding as determined by ultrafiltration in pooled serum was 94.7-96.2% for flucloxacillin and 96.4-97.2% for dicloxacillin. The serum bactericidal titers were similar for the two drugs. In conclusion, dicloxacillin and flucloxacillin showed similar pharmacokinetic behavior after 0.75 g doses in human volunteers.

UI MeSH Term Description Entries
D008297 Male Males
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D011485 Protein Binding The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. Plasma Protein Binding Capacity,Binding, Protein
D001798 Blood Proteins Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins. Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D004009 Dicloxacillin One of the PENICILLINS which is resistant to PENICILLINASE. Dichloroxacillin,Cilpen,Diclocil,Dicloxaciclin,Dicloxacillin Sodium,Dicloxacillin, Monosodium Salt, Anhydrous,Dicloxacillin, Monosodium Salt, Mono-Hydrate,Dicloxacycline,Dicloxsig,Distaph,Ditterolina,Dycill,Dynapen,InfectoStaph,Pathocil,Posipen,Sodium, Dicloxacillin
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260 Female Females
D005436 Floxacillin Antibiotic analog of CLOXACILLIN. Flucloxacillin,Fluorochloroxacillin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations

Related Publications

B L Røder, and N Frimodt-Møller, and F Espersen, and S N Rasmussen
Re: B. L. Røder, et al.: Dicloxacillin and flucloxacillin: pharmacokinetics, protein binding and serum bactericidal titers in healthy subjects after oral administration (Infection 23 [1995] 107-112)
January 1996, Infection,
B L Røder, and N Frimodt-Møller, and F Espersen, and S N Rasmussen
Pharmacokinetics and serum bactericidal titers of ciprofloxacin and ofloxacin following multiple oral doses in healthy volunteers.
October 1993, Antimicrobial agents and chemotherapy,
B L Røder, and N Frimodt-Møller, and F Espersen, and S N Rasmussen
Dicloxacillin pharmacokinetics in dogs after intravenous, intramuscular and oral administration.
October 1998, Journal of veterinary pharmacology and therapeutics,
B L Røder, and N Frimodt-Møller, and F Espersen, and S N Rasmussen
Pharmacokinetics of phenprobamate after oral administration to healthy subjects.
November 1998, Arzneimittel-Forschung,
B L Røder, and N Frimodt-Møller, and F Espersen, and S N Rasmussen
Pharmacokinetics of centchroman in healthy female subjects after oral administration.
November 1995, Contraception,
B L Røder, and N Frimodt-Møller, and F Espersen, and S N Rasmussen
Dicloxacillin and cloxacillin: pharmacokinetics in healthy and hemodialysis subjects.
July 1976, Clinical pharmacology and therapeutics,
B L Røder, and N Frimodt-Møller, and F Espersen, and S N Rasmussen
Pharmacokinetics of clentiazem after intravenous and oral administration in healthy subjects.
April 1993, Journal of clinical pharmacology,
B L Røder, and N Frimodt-Møller, and F Espersen, and S N Rasmussen
Pharmacokinetics of ketotifen after oral administration to healthy male subjects.
May 1992, Biopharmaceutics & drug disposition,
B L Røder, and N Frimodt-Møller, and F Espersen, and S N Rasmussen
Comparative pharmacokinetics of midazolam and loprazolam in healthy subjects after oral administration.
January 1986, Biopharmaceutics & drug disposition,
B L Røder, and N Frimodt-Møller, and F Espersen, and S N Rasmussen
Pharmacokinetics and pharmacodynamics of clomethiazole after oral and rectal administration in healthy subjects.
May 1999, Clinical therapeutics,
Copied contents to your clipboard!