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In a continuing effort to investigate biological activities of flavonoids, nine biflavonoids, isolated from three plant sources were evaluated for their suppressive effects on mouse lymphocyte proliferation. The biflavonoids tested were amentoflavone, bilobetin, ginkgetin, isoginkgetin, sciadopitysin, ochnaflavone, 4'-O-methylochnaflavone, cryptomerin B and isocryptomerin. At 10 uM, several biflavonoids such as ginkgetin, isoginkgetin, ochnaflavone, cryptomerin B and isocryptomerin showed the suppressive activity against lymphocyte proliferation induced by Con A or LPS. Apigenin (flavone) and quercetin (flavonol) were suppressive against Con A-induced lymphocyte proliferation, but not against LPS-induced lymphocyte proliferation at the same concentration range. Biflavonoids were found to be irreversible inhibitors of lymphocyte proliferation. This is the first report describing the suppressive effects of naturally-occurring biflavonoids against lymphocyte proliferation.
S J Lee, and
J H Choi, and
K H Son, and
H W Chang, and
S S Kang, and
H P Kim
July 2012,
Journal of traditional and complementary medicine,
S J Lee, and
J H Choi, and
K H Son, and
H W Chang, and
S S Kang, and
H P Kim
January 1988,
Advances in biochemical psychopharmacology,
S J Lee, and
J H Choi, and
K H Son, and
H W Chang, and
S S Kang, and
H P Kim
April 1985,
The Australian journal of experimental biology and medical science,
S J Lee, and
J H Choi, and
K H Son, and
H W Chang, and
S S Kang, and
H P Kim
January 1994,
Life sciences,
S J Lee, and
J H Choi, and
K H Son, and
H W Chang, and
S S Kang, and
H P Kim
February 1984,
International journal for parasitology,
S J Lee, and
J H Choi, and
K H Son, and
H W Chang, and
S S Kang, and
H P Kim
June 1989,
Toxicology,
S J Lee, and
J H Choi, and
K H Son, and
H W Chang, and
S S Kang, and
H P Kim
January 1980,
Cellular immunology,
S J Lee, and
J H Choi, and
K H Son, and
H W Chang, and
S S Kang, and
H P Kim
August 1993,
The Journal of experimental medicine,
S J Lee, and
J H Choi, and
K H Son, and
H W Chang, and
S S Kang, and
H P Kim
June 1984,
The Journal of biological chemistry,
S J Lee, and
J H Choi, and
K H Son, and
H W Chang, and
S S Kang, and
H P Kim
October 1992,
International journal of immunopharmacology,
