The rodent dominant lethal assay: a proposed format for data presentation that alerts to pseudo-dominant lethal effects. 1995

J Ashby, and M J Clapp
Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, UK.

The rodent dominant lethal (DL) germ cell mutagenicity assay is the primary test for possible human germ cell mutagens. As such, it occupies a critical regulatory position. DL assay data are often difficult to assess because of the quantity of data involved, and because several related assay parameters require to be considered simultaneously. To reduce this difficulty a schematic method of data presentation is proposed and illustrated. This method enables the most pertinent assay data and parameters to be viewed and considered simultaneously. Using this format of data presentation, existing DL studies on cyclophosphamide, methylnitrosourea, diethylhexylphthalate, divinyl sulphone, methyl methanesulphonate, 6-mercaptopurine and ethylenethiourea are re-analysed.

UI MeSH Term Description Entries
D008297 Male Males
D009152 Mutagenicity Tests Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests. Genetic Toxicity Tests,Genotoxicity Tests,Mutagen Screening,Tests, Genetic Toxicity,Toxicity Tests, Genetic,Genetic Toxicity Test,Genotoxicity Test,Mutagen Screenings,Mutagenicity Test,Screening, Mutagen,Screenings, Mutagen,Test, Genotoxicity,Tests, Genotoxicity,Toxicity Test, Genetic
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D003626 Data Display The visual representation of data via a manufactured system. Information Display,Data Displays,Display, Data,Display, Information,Displays, Data,Displays, Information,Information Displays
D003627 Data Interpretation, Statistical Application of statistical procedures to analyze specific observed or assumed facts from a particular study. Data Analysis, Statistical,Data Interpretations, Statistical,Interpretation, Statistical Data,Statistical Data Analysis,Statistical Data Interpretation,Analyses, Statistical Data,Analysis, Statistical Data,Data Analyses, Statistical,Interpretations, Statistical Data,Statistical Data Analyses,Statistical Data Interpretations
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260 Female Females
D005298 Fertility The capacity to conceive or to induce conception. It may refer to either the male or female. Fecundity,Below Replacement Fertility,Differential Fertility,Fecundability,Fertility Determinants,Fertility Incentives,Fertility Preferences,Fertility, Below Replacement,Marital Fertility,Natural Fertility,Subfecundity,World Fertility Survey,Determinant, Fertility,Determinants, Fertility,Fertility Determinant,Fertility Incentive,Fertility Preference,Fertility Survey, World,Fertility Surveys, World,Fertility, Differential,Fertility, Marital,Fertility, Natural,Preference, Fertility,Preferences, Fertility,Survey, World Fertility,Surveys, World Fertility,World Fertility Surveys
D005313 Fetal Death Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH. Fetal Mummification,Fetal Demise,Death, Fetal,Deaths, Fetal,Demise, Fetal,Fetal Deaths,Mummification, Fetal
D005799 Genes, Dominant Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state. Conditions, Dominant Genetic,Dominant Genetic Conditions,Genetic Conditions, Dominant,Condition, Dominant Genetic,Dominant Gene,Dominant Genes,Dominant Genetic Condition,Gene, Dominant,Genetic Condition, Dominant

Related Publications

J Ashby, and M J Clapp
January 1994, Environmental and molecular mutagenesis,
J Ashby, and M J Clapp
May 2000, Mutation research,
J Ashby, and M J Clapp
December 1989, MMWR. Morbidity and mortality weekly report,
J Ashby, and M J Clapp
December 1977, Toxicology and applied pharmacology,
J Ashby, and M J Clapp
October 1995, Mutation research,
J Ashby, and M J Clapp
March 1989, International journal of radiation oncology, biology, physics,
J Ashby, and M J Clapp
October 1987, Mutation research,
J Ashby, and M J Clapp
June 1973, Agents and actions,
Copied contents to your clipboard!