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An updated review of the genotoxicity studies with acrylamide is provided. Then, using data from the studies generating quantitative information concerning heritability of genetic effects, an assessment of the heritable genetic risk presented by acrylamide is presented. The review offers a discussion of the reactions and possible mechanisms of genotoxic action by acrylamide and its epoxide metabolite glycidamide. Several genetic risk approaches are discussed, including the parallelogram, direct (actually a modified direct), and doubling dose approaches. Using data from the specific-locus and heritable translocation assays, the modified direct and doubling dose approaches are utilized to quantitate genetic risk. Exposures of male parents to acrylamide via inhalation, ingestion, and dermal routes are also quantitated. With these approaches and measurements and their underlying assumptions concerning extrapolation factors (including germ cell stage specificity, DNA repair variability, locus specificity), number of human loci associated with dominant disease alleles, and spontaneous mutation rates, an assessment of heritable genetic risk for humans is calculated for the three exposure scenarios. The calculated estimates for offspring from fathers exposed to acrylamide via drinking water are up to three offspring potentially affected with induced genetic disease per 10(8) offspring. Estimates for inhalation or dermal exposures suggest higher risks for induced genetic disease in offspring from fathers exposed in occupational settings.
K L Dearfield, and
G R Douglas, and
U H Ehling, and
M M Moore, and
G A Sega, and
D J Brusick
May 2022,
EFSA journal. European Food Safety Authority,
K L Dearfield, and
G R Douglas, and
U H Ehling, and
M M Moore, and
G A Sega, and
D J Brusick
January 2006,
Annali dell'Istituto superiore di sanita,
K L Dearfield, and
G R Douglas, and
U H Ehling, and
M M Moore, and
G A Sega, and
D J Brusick
January 1980,
Teratogenesis, carcinogenesis, and mutagenesis,
K L Dearfield, and
G R Douglas, and
U H Ehling, and
M M Moore, and
G A Sega, and
D J Brusick
January 2016,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K L Dearfield, and
G R Douglas, and
U H Ehling, and
M M Moore, and
G A Sega, and
D J Brusick
August 1995,
Mutation research,
K L Dearfield, and
G R Douglas, and
U H Ehling, and
M M Moore, and
G A Sega, and
D J Brusick
August 1995,
Mutation research,
K L Dearfield, and
G R Douglas, and
U H Ehling, and
M M Moore, and
G A Sega, and
D J Brusick
January 1988,
Mutation research,
K L Dearfield, and
G R Douglas, and
U H Ehling, and
M M Moore, and
G A Sega, and
D J Brusick
July 2004,
Journal of the National Cancer Institute,
K L Dearfield, and
G R Douglas, and
U H Ehling, and
M M Moore, and
G A Sega, and
D J Brusick
September 2020,
Archives of toxicology,
K L Dearfield, and
G R Douglas, and
U H Ehling, and
M M Moore, and
G A Sega, and
D J Brusick
February 2005,
Regulatory toxicology and pharmacology : RTP,
