Inactivation of simian immunodeficiency virus by hydrostatic pressure. 1995

E Jurkiewicz, and M Villas-Boas, and J L Silva, and G Weber, and G Hunsmann, and R M Clegg
Abteilung Virologie und Immunologie, Deutsches Primatenzentrum GmbH, GĂ´ttigen, Germany.

The inactivation of the simian immunodeficiency viruses SIVmac251 and SIVagm by pressures of 150 and 250 MPa was determined. The extent of inactivation depended on the time that the virus was subjected to compression as well as the level of the pressure and at 150 Mpa reached 5 log10 dilution units after approximately 10 hr. The inactivations, which were uniformly carried out at room temperature, were independent of the concentration of the virus. Possible applications of pressure inactivation for molecular biological and clinical use are discussed.

UI MeSH Term Description Entries
D006874 Hydrostatic Pressure The pressure due to the weight of fluid. Hydrostatic Pressures,Pressure, Hydrostatic,Pressures, Hydrostatic
D013242 Sterilization The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D015302 Simian Immunodeficiency Virus Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV. SIV (Simian immunodeficiency virus),Immunodeficiency Viruses, Simian,Simian Immunodeficiency Viruses,Immunodeficiency Virus, Simian

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