-transparent.png){kind=logo}
The inhibitory effect of probucol on ferrous-iron-induced microsomal lipid peroxidation was compared to that of alpha-tocopherol and butylated hydroxytoluene (BHT). Male Wistar rats were fed with diets containing 1% probucol, 0.2% BHT or 0.1% alpha-tocopherol for 30 days. There were no effects of dietary antioxidants on growth parameters, although liver weight was significantly higher in the BHT-fed rats. Probucol reduced serum levels of total and free cholesterol, while BHT feeding increased the concentrations of serum thiobarbituric-acid-reactive substances, HDL cholesterol and hepatic phospholipid. alpha-Tocopherol had no effect on these parameters. Incorporation of both, probucol and alpha-tocopherol, decreased the susceptibility of microsomes to lipid peroxidation in vitro, while BHT incorporation increased hepatic microsomal lipid peroxidation. These results suggest the possible usefulness of probucol for treatment of both hypercholesterolemia and elevated hepatic microsomal lipid peroxidation, while alpha-tocopherol decreases only an elevated lipid peroxidation. BHT works as a prooxidant.
K Yamamoto, and
N Fukuda, and
S Shiroi, and
Y Shiotsuki, and
Y Nagata, and
T Tani, and
T Sakai
January 1995,
Biological trace element research,
K Yamamoto, and
N Fukuda, and
S Shiroi, and
Y Shiotsuki, and
Y Nagata, and
T Tani, and
T Sakai
February 2000,
Phytotherapy research : PTR,
K Yamamoto, and
N Fukuda, and
S Shiroi, and
Y Shiotsuki, and
Y Nagata, and
T Tani, and
T Sakai
October 1976,
Life sciences,
K Yamamoto, and
N Fukuda, and
S Shiroi, and
Y Shiotsuki, and
Y Nagata, and
T Tani, and
T Sakai
January 1991,
Free radical research communications,
K Yamamoto, and
N Fukuda, and
S Shiroi, and
Y Shiotsuki, and
Y Nagata, and
T Tani, and
T Sakai
February 2005,
Journal of agricultural and food chemistry,
K Yamamoto, and
N Fukuda, and
S Shiroi, and
Y Shiotsuki, and
Y Nagata, and
T Tani, and
T Sakai
December 1993,
Mechanisms of ageing and development,
K Yamamoto, and
N Fukuda, and
S Shiroi, and
Y Shiotsuki, and
Y Nagata, and
T Tani, and
T Sakai
December 1975,
Toxicology and applied pharmacology,
K Yamamoto, and
N Fukuda, and
S Shiroi, and
Y Shiotsuki, and
Y Nagata, and
T Tani, and
T Sakai
December 1987,
Journal of applied toxicology : JAT,
K Yamamoto, and
N Fukuda, and
S Shiroi, and
Y Shiotsuki, and
Y Nagata, and
T Tani, and
T Sakai
April 1980,
Biochimica et biophysica acta,
K Yamamoto, and
N Fukuda, and
S Shiroi, and
Y Shiotsuki, and
Y Nagata, and
T Tani, and
T Sakai
August 1992,
Biochemical pharmacology,
