Biomaterial Database

Brain damage complicating septic shock: acute haemorrhagic leucoencephalitis as a complication of the generalised Shwartzman reaction. 1979

D I Graham, and P O Behan, and I A More

The neuropathological findings in six patients who developed neurological signs after the onset of "septic shock" caused by Gram-negative septicaemia are described. The changes in the brains were characteristic of acute haemorrhagic leucoencephalitis, and there was evidence, particularly in the kidneys, of disseminated intravascular coagulation with tubular necrosis and, in some, appearances indistinguishable from membrano-proliferative glomerulonephritis. It is agreed that acute haemorrhagic leucoencephalitis is another manifestation of a generalised Shwartzman reaction, and it is suggested that activation of complement is the final common pathway that produces tissue damage in the brain and kidney.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D001925	Brain Damage, Chronic	A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.	Encephalopathy, Chronic,Chronic Encephalopathy,Chronic Brain Damage
D001933	Brain Stem	The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.	Brainstem,Truncus Cerebri,Brain Stems,Brainstems,Cerebri, Truncus,Cerebrus, Truncus,Truncus Cerebrus
D002531	Cerebellum	The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.	Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D002540	Cerebral Cortex	The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.	Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D004679	Encephalomyelitis	A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.	Myeloencephalitis,Encephalomyelitis, Inflammatory,Inflammatory Encephalomyelitis,Myeloencephalitides
D004684	Leukoencephalitis, Acute Hemorrhagic	A fulminant and often fatal demyelinating disease of the brain which primarily affects young adults and children. Clinical features include the rapid onset of weakness, SEIZURES, and COMA. It may follow a viral illness or MYCOPLASMA PNEUMONIAE infections but in most instances there is no precipitating event. Pathologic examination reveals marked perivascular demyelination and necrosis of white matter with microhemorrhages. (Adams et al., Principles of Neurology, 6th ed, pp924-5)	Encephalitis, Acute Necrotizing,Hurst Disease,Necrotizing Hemorrhagic Encephalomyelitis,Acute Hemorrhagic Encephalomyelitis,Acute Hemorrhagic Leukoencephalitis,Encephalomyelitis, Acute Necrotizing Hemorrhagic,Encephalomyelitis, Hemorrhagic Necrotizing,Encephalomyelitis, Necrotizing Hemorrhagic,Hemorrhagic Encephalomyelitis, Necrotizing,Hemorrhagic Necrotizing Encephalomyelitis,Hurst Syndrome,Hurst's Disease,Leukoencephalitis Acuta Hemorrhagica,Leukoencephalitis, Subacute Hemorrhagic,Necrotizing Encephalomyelitis, Hemorrhagic,Acute Hemorrhagic Encephalomyelitides,Acute Hemorrhagic Leukoencephalitides,Acute Necrotizing Encephalitides,Acute Necrotizing Encephalitis,Disease, Hurst,Disease, Hurst's,Encephalitides, Acute Necrotizing,Encephalomyelitides, Acute Hemorrhagic,Encephalomyelitides, Hemorrhagic Necrotizing,Encephalomyelitis, Acute Hemorrhagic,Hemorrhagic Encephalomyelitides, Acute,Hemorrhagic Encephalomyelitides, Necrotizing,Hemorrhagic Encephalomyelitis, Acute,Hemorrhagic Leukoencephalitides, Acute,Hemorrhagic Leukoencephalitides, Subacute,Hemorrhagic Leukoencephalitis, Acute,Hemorrhagic Leukoencephalitis, Subacute,Hursts Disease,Leukoencephalitides, Acute Hemorrhagic,Leukoencephalitides, Subacute Hemorrhagic,Necrotizing Encephalitides, Acute,Necrotizing Encephalitis, Acute,Necrotizing Encephalomyelitides, Hemorrhagic,Necrotizing Hemorrhagic Encephalomyelitides,Subacute Hemorrhagic Leukoencephalitides,Subacute Hemorrhagic Leukoencephalitis,Syndrome, Hurst
D005260	Female		Females