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The antioxidant effects of Ginkgo biloba extract (EGb 761) on copper-mediated human low density lipoprotein (LDL) oxidative modification were evaluated by several techniques. Human LDL (0.5 mg/ml) in phosphate buffered saline, pH 7.4, was incubated with 10 microM cupric sulfate at 37 degrees C under air for 8 hours and 24 hours in the presence of varying concentrations of EGb 761. Increases in LDL apoB carbonylation, lipid peroxidation, apoB electrophoretic mobility and LDL fluorescence were all inhibited when the incubation mixture contained EGb 761 at concentrations less than 100 micrograms/ml. This inhibition was EGb 761-concentration-dependent. Thus, EGb 761 has powerful antioxidant effects on copper-mediated LDL oxidative modification.
L J Yan, and
M T Droy-Lefaix, and
L Packer
October 2008,
Cellular and molecular biology (Noisy-le-Grand, France),
L J Yan, and
M T Droy-Lefaix, and
L Packer
September 2007,
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology,
L J Yan, and
M T Droy-Lefaix, and
L Packer
January 2003,
Drugs in R&D,
L J Yan, and
M T Droy-Lefaix, and
L Packer
January 1998,
Free radical biology & medicine,
L J Yan, and
M T Droy-Lefaix, and
L Packer
January 2004,
Current pharmaceutical design,
L J Yan, and
M T Droy-Lefaix, and
L Packer
July 2002,
Hearing research,
L J Yan, and
M T Droy-Lefaix, and
L Packer
June 2000,
The European journal of neuroscience,
L J Yan, and
M T Droy-Lefaix, and
L Packer
September 1986,
Presse medicale (Paris, France : 1983),
L J Yan, and
M T Droy-Lefaix, and
L Packer
January 1994,
Methods in enzymology,
L J Yan, and
M T Droy-Lefaix, and
L Packer
December 2007,
Pharmacological research,
