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Oligonucleotides complementary to the sequences containing the initiator codon, AUG, of the core region of positive-stranded hepatitis C virus (HCV) were tested for their effects on viral translation in a cell-free protein synthesis system and on viral replication in a human T-lymphotropic virus type I infected cell line, MT-2C, which was cloned by the limited dilution method from MT-2 cells and showed more efficient HCV replication than an uncloned population of MT-2 cells. Treatment of HCV-infected MT-2C cells with the antisense oligonucleotide (10 microM) had a dramatic inhibitory effect on viral replication. This result suggests that the antisense oligonucleotide complementary to the sequence close to the initiation codon of the core region might be useful as an antiviral agent against HCV replication.
T Mizutani, and
N Kato, and
M Hirota, and
K Sugiyama, and
A Murakami, and
K Shimotohno
June 2006,
Cancer cell international,
T Mizutani, and
N Kato, and
M Hirota, and
K Sugiyama, and
A Murakami, and
K Shimotohno
August 1996,
Journal of virology,
T Mizutani, and
N Kato, and
M Hirota, and
K Sugiyama, and
A Murakami, and
K Shimotohno
December 1996,
Antiviral research,
T Mizutani, and
N Kato, and
M Hirota, and
K Sugiyama, and
A Murakami, and
K Shimotohno
January 1995,
Antisense research and development,
T Mizutani, and
N Kato, and
M Hirota, and
K Sugiyama, and
A Murakami, and
K Shimotohno
January 1993,
Advances in experimental medicine and biology,
T Mizutani, and
N Kato, and
M Hirota, and
K Sugiyama, and
A Murakami, and
K Shimotohno
August 1997,
Zhonghua yi xue za zhi,
T Mizutani, and
N Kato, and
M Hirota, and
K Sugiyama, and
A Murakami, and
K Shimotohno
September 1995,
Acta virologica,
T Mizutani, and
N Kato, and
M Hirota, and
K Sugiyama, and
A Murakami, and
K Shimotohno
August 2004,
Antimicrobial agents and chemotherapy,
T Mizutani, and
N Kato, and
M Hirota, and
K Sugiyama, and
A Murakami, and
K Shimotohno
October 2005,
Antimicrobial agents and chemotherapy,
T Mizutani, and
N Kato, and
M Hirota, and
K Sugiyama, and
A Murakami, and
K Shimotohno
July 2011,
Journal of viral hepatitis,
