BIOMAT Database Logo BIOMAT Database Logo

Natural killer cell activity in patients with pernicious anemia. 1995

J A Vargas, and M Alvarez-Mon, and L Manzano, and A Albillos, and A Fernández-Corugedo, and J C Gea-Banacloche, and F M Gonzalez, and A Durántez
Service of Internal Medicine I, Clínica Puerta de Hierro, Universidad Autónoma, Madrid, Spain.

Patients with pernicious anemia have an estimated risk of gastric adenocarcinoma that ranges from three- to fivefold greater than that of the general population. It has been reported that NK cells may be involved in immunosurveillance against tumor spread. The natural killer cell activity of peripheral blood mononuclear cells was analyzed in 22 patients with pernicious anemia and in 19 healthy controls. Levels of natural killer cell activity against K-562 target cells were similar in control subjects and patients, regardless of gastrin levels and time elapsed since diagnosis. According to quantitative flow cytometry analysis, similar percentages of phenotypically defined NK cells (CD16+) were found in peripheral blood mononuclear cells from patients and healthy controls. Our results show that in pernicious anemia patients, the percentage of NK cells present in peripheral blood mononuclear cells and their lytic activity are normal.

UI MeSH Term Description Entries
D007694 Killer Cells, Natural Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type. NK Cells,Natural Killer Cells,Cell, NK,Cell, Natural Killer,Cells, NK,Cells, Natural Killer,Killer Cell, Natural,NK Cell,Natural Killer Cell
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003601 Cytotoxicity Tests, Immunologic The demonstration of the cytotoxic effect on a target cell of a lymphocyte, a mediator released by a sensitized lymphocyte, an antibody, or complement. AHG-CDC Tests,Anti-Human Globulin Complement-Dependent Cytotoxicity Tests,Microcytotoxicity Tests,Anti Human Globulin Complement Dependent Cytotoxicity Tests,Anti-Human Globulin Complement-Dependent Cytotoxicity Test,Antiglobulin-Augmented Lymphocytotoxicity Test,Antiglobulin-Augmented Lymphocytotoxicity Tests,Cytotoxicity Test, Immunologic,Cytotoxicity Tests, Anti-Human Globulin Complement-Dependent,Cytotoxicity Tests, Immunological,Immunologic Cytotoxicity Test,Immunologic Cytotoxicity Tests,Lymphocytotoxicity Test, Antiglobulin-Augmented,Lymphocytotoxicity Tests, Antiglobulin-Augmented,Microcytotoxicity Test,AHG CDC Tests,AHG-CDC Test,Anti Human Globulin Complement Dependent Cytotoxicity Test,Antiglobulin Augmented Lymphocytotoxicity Test,Antiglobulin Augmented Lymphocytotoxicity Tests,Cytotoxicity Test, Immunological,Cytotoxicity Tests, Anti Human Globulin Complement Dependent,Immunological Cytotoxicity Test,Immunological Cytotoxicity Tests,Lymphocytotoxicity Test, Antiglobulin Augmented,Lymphocytotoxicity Tests, Antiglobulin Augmented
D005260 Female Females
D005755 Gastrins A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters. Gastrin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D000752 Anemia, Pernicious A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed) Addison's Anemia,Anemia, Addison's,Pernicious Anemia,Addison Anemia,Addisons Anemia,Anemia, Addison,Anemia, Addisons

Related Publications

J A Vargas, and M Alvarez-Mon, and L Manzano, and A Albillos, and A Fernández-Corugedo, and J C Gea-Banacloche, and F M Gonzalez, and A Durántez
Depression of natural killer cell activity in patients with aplastic anemia.
July 1985, Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
J A Vargas, and M Alvarez-Mon, and L Manzano, and A Albillos, and A Fernández-Corugedo, and J C Gea-Banacloche, and F M Gonzalez, and A Durántez
[Natural killer activity of peripheral blood in patients with aplastic anemia].
June 1986, Zhonghua nei ke za zhi,
J A Vargas, and M Alvarez-Mon, and L Manzano, and A Albillos, and A Fernández-Corugedo, and J C Gea-Banacloche, and F M Gonzalez, and A Durántez
Natural killer cell activity in patients with panic disorder.
January 1994, Anxiety,
J A Vargas, and M Alvarez-Mon, and L Manzano, and A Albillos, and A Fernández-Corugedo, and J C Gea-Banacloche, and F M Gonzalez, and A Durántez
Natural killer cell activity in patients with multiple myeloma.
January 1988, Cancer detection and prevention,
J A Vargas, and M Alvarez-Mon, and L Manzano, and A Albillos, and A Fernández-Corugedo, and J C Gea-Banacloche, and F M Gonzalez, and A Durántez
[Natural killer cell activity in patients with nasopharyngeal carcinoma].
August 1986, Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology,
J A Vargas, and M Alvarez-Mon, and L Manzano, and A Albillos, and A Fernández-Corugedo, and J C Gea-Banacloche, and F M Gonzalez, and A Durántez
Natural killer cell activity in patients with urologic cancer.
January 1987, European urology,
J A Vargas, and M Alvarez-Mon, and L Manzano, and A Albillos, and A Fernández-Corugedo, and J C Gea-Banacloche, and F M Gonzalez, and A Durántez
[Natural killer cell activity in patients with focal scleroderma].
January 1986, Vestnik dermatologii i venerologii,
J A Vargas, and M Alvarez-Mon, and L Manzano, and A Albillos, and A Fernández-Corugedo, and J C Gea-Banacloche, and F M Gonzalez, and A Durántez
Natural killer cell activity in patients with cervical cancer.
November 1983, The Indian journal of medical research,
J A Vargas, and M Alvarez-Mon, and L Manzano, and A Albillos, and A Fernández-Corugedo, and J C Gea-Banacloche, and F M Gonzalez, and A Durántez
Natural killer cell activity in patients with Behćet's disease.
December 1984, American journal of ophthalmology,
J A Vargas, and M Alvarez-Mon, and L Manzano, and A Albillos, and A Fernández-Corugedo, and J C Gea-Banacloche, and F M Gonzalez, and A Durántez
Reduced natural killer activity in patients with Fanconi's anemia and in family members.
January 1987, Leukemia research,
Copied contents to your clipboard!