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[The effect of lactitol (NS-4) on the concentrations of ammonia and amino acids in blood and cerebrospinal fluid in Eck fistula (portacaval-shunted) dogs]. 1995

M Watanabe, and T Ozaki, and Y Hirata, and Y Yoshikuni, and K Kimura, and K Suzuki, and S Sato
Research Laboratories, Nippon Shinyaku Co. Ltd., Kyoto, Japan.

Lactitol and lactulose were compared in their effect on the concentrations of ammonia and amino acids in blood and cerebrospinal fluid (CSF) in Eck fistula dogs. Drugs were administered intragastrically for four weeks from three weeks after the portacaval-shunt operation. The concentration of ammonia in the blood and CSF had increased three- to five-fold three weeks after the operation and increased gradually thereafter. Eck fistula dogs showed a characteristic profile of plasma amino acids, with increased concentrations of tryptophan (Trp) and aromatic amino acids (AAA) and reduced concentrations of branched-chain amino acids. The profile of CSF amino acids revealed substantial increases in the concentrations of AAA as well as glutamine (Gln), Trp and glutamic acid. Lactitol at doses of 1 and 3 g/kg/day significantly decreased the ammonia concentration in both the blood and CSF after administration for two and four weeks. Lactitol at a dose of 3 g/kg/day significantly decreased the concentration of Trp in the plasma and the concentrations of valine, leucine, AAA and Gln in CSF. Lactulose showed effects similar to those of lactitol. These findings suggest that lactitol may be a promising agent for the clinical treatment of hyperammonemia and hepatic encephalopathy, since it decreased the concentration of ammonia in the blood and CSF and the elevated concentrations of AAA in CSF associated with the development of hepatic encephalopathy.

UI MeSH Term Description Entries
D007792 Lactulose A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887) Amivalex,Duphalac,Normase
D008297 Male Males
D011167 Portacaval Shunt, Surgical Surgical portasystemic shunt between the portal vein and inferior vena cava. Eck Fistula,Portacaval Anastomosis,Portacaval Shunt,Shunt, Surgical Portacaval,Surgical Portacaval Shunt,Anastomoses, Portacaval,Anastomosis, Portacaval,Fistula, Eck,Portacaval Anastomoses,Portacaval Shunts,Portacaval Shunts, Surgical,Shunt, Portacaval,Shunts, Portacaval,Shunts, Surgical Portacaval,Surgical Portacaval Shunts
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D006501 Hepatic Encephalopathy A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5) Encephalopathy, Hepatic,Portosystemic Encephalopathy,Encephalopathy, Hepatocerebral,Encephalopathy, Portal-Systemic,Encephalopathy, Portosystemic,Fulminant Hepatic Failure with Cerebral Edema,Hepatic Coma,Hepatic Stupor,Hepatocerebral Encephalopathy,Portal-Systemic Encephalopathy,Coma, Hepatic,Comas, Hepatic,Encephalopathies, Hepatic,Encephalopathies, Hepatocerebral,Encephalopathies, Portal-Systemic,Encephalopathies, Portosystemic,Encephalopathy, Portal Systemic,Hepatic Comas,Hepatic Encephalopathies,Hepatic Stupors,Hepatocerebral Encephalopathies,Portal Systemic Encephalopathy,Portal-Systemic Encephalopathies,Portosystemic Encephalopathies,Stupor, Hepatic,Stupors, Hepatic
D000596 Amino Acids Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins. Amino Acid,Acid, Amino,Acids, Amino
D000641 Ammonia A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013402 Sugar Alcohols Polyhydric alcohols having no more than one hydroxy group attached to each carbon atom. They are formed by the reduction of the carbonyl group of a sugar to a hydroxyl group. (From Dorland, 28th ed) Alcohols, Sugar,Alditol,Sugar Alcohol,Alditols,Alcohol, Sugar

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