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Adrenomedullin is known to induce profound hypotension in vivo, but the direct effect of this peptide on isolated arteries has not been demonstrated. This study estimated the vasodilative effects of adrenomedullin in comparison with those of calcitonin gene-related peptide (CGRP) in basilar, mesenteric, coronary, renal and femoral arteries isolated from the dog. Adrenomedullin (3 to 100 nM) and CGRP (1 to 30 nM) induced concentration-dependent relaxation of these arteries with and without endothelium, and the relaxing effects were slightly greater in endothelium-intact arteries than in denuded ones. The vasodilative potency of adrenomedullin relative to CGRP was smaller in the femoral artery than in basilar, mesenteric, coronary and renal arteries.
K Nakamura, and
H Toda, and
K Terasako, and
M Kakuyama, and
Y Hatano, and
K Mori, and
K Kangawa
May 2005,
Phytomedicine : international journal of phytotherapy and phytopharmacology,
K Nakamura, and
H Toda, and
K Terasako, and
M Kakuyama, and
Y Hatano, and
K Mori, and
K Kangawa
January 1997,
Investigative ophthalmology & visual science,
K Nakamura, and
H Toda, and
K Terasako, and
M Kakuyama, and
Y Hatano, and
K Mori, and
K Kangawa
September 1985,
Japanese journal of pharmacology,
K Nakamura, and
H Toda, and
K Terasako, and
M Kakuyama, and
Y Hatano, and
K Mori, and
K Kangawa
February 2004,
Investigative ophthalmology & visual science,
K Nakamura, and
H Toda, and
K Terasako, and
M Kakuyama, and
Y Hatano, and
K Mori, and
K Kangawa
December 1999,
European journal of pharmacology,
K Nakamura, and
H Toda, and
K Terasako, and
M Kakuyama, and
Y Hatano, and
K Mori, and
K Kangawa
January 1993,
Life sciences,
K Nakamura, and
H Toda, and
K Terasako, and
M Kakuyama, and
Y Hatano, and
K Mori, and
K Kangawa
March 1984,
Cardiovascular research,
K Nakamura, and
H Toda, and
K Terasako, and
M Kakuyama, and
Y Hatano, and
K Mori, and
K Kangawa
November 1983,
Archives internationales de pharmacodynamie et de therapie,
K Nakamura, and
H Toda, and
K Terasako, and
M Kakuyama, and
Y Hatano, and
K Mori, and
K Kangawa
July 1987,
Japanese journal of pharmacology,
K Nakamura, and
H Toda, and
K Terasako, and
M Kakuyama, and
Y Hatano, and
K Mori, and
K Kangawa
April 1988,
Agents and actions,
