-transparent.png){kind=logo}
Tablets containing the inclusion complex of ursodeoxycholic acid (UDCA) with 2-hydroxypropyl-beta-cyclodextrin were prepared by direct compression. Plasma concentrations of UDCA were determined in six healthy volunteers after oral administration of tablets containing the inclusion complex or UDCA alone (Ursacol). Following the administration of the complex tablets, the mean area under the plasma concentration curve (AUC) and the maximum UDCA plasma concentration (Cmax) were significantly higher than those obtained after the administration of the commercial ones. Moreover, the time of maximum plasma concentration (tmax) appeared at a shorter time. These results may be explained by the increase of the UDCA dissolution rate via complex formation.
R Panini, and
M A Vandelli, and
F Forni, and
J M Pradelli, and
G Salvioli
January 2000,
Pharmaceutical development and technology,
R Panini, and
M A Vandelli, and
F Forni, and
J M Pradelli, and
G Salvioli
July 1998,
Antimicrobial agents and chemotherapy,
R Panini, and
M A Vandelli, and
F Forni, and
J M Pradelli, and
G Salvioli
December 2009,
Applied biochemistry and biotechnology,
R Panini, and
M A Vandelli, and
F Forni, and
J M Pradelli, and
G Salvioli
February 1983,
Journal of pharmacobio-dynamics,
R Panini, and
M A Vandelli, and
F Forni, and
J M Pradelli, and
G Salvioli
November 2003,
Drug development and industrial pharmacy,
R Panini, and
M A Vandelli, and
F Forni, and
J M Pradelli, and
G Salvioli
November 1999,
International journal of pharmaceutics,
R Panini, and
M A Vandelli, and
F Forni, and
J M Pradelli, and
G Salvioli
April 2011,
PloS one,
R Panini, and
M A Vandelli, and
F Forni, and
J M Pradelli, and
G Salvioli
January 2010,
Pharmaceutical development and technology,
R Panini, and
M A Vandelli, and
F Forni, and
J M Pradelli, and
G Salvioli
January 2018,
Drug design, development and therapy,
R Panini, and
M A Vandelli, and
F Forni, and
J M Pradelli, and
G Salvioli
November 1988,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
