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Triiodothyronine (T3) kinetic studies were carried out using 126I-T3 and the single injection technique in eight clinically euthyroid patients with autonomous thyroid nodules and the metabolic results were compared to those obtained in a group of 12 healthy control subjects. Plasma labeled T3 concentration was measured by a chromatographic method based on the extraction of the hormone on Sephadex G-25 columns, followed by its elution with a specific anti-T3 antiserum. The analysis of the experimental plasma disappearance curves of the labeled hormone was performed using the noncompartmental method. The results obtained showed a significantly increased metabolic clearance rate of T3 in the patients with autonomous thyroid nodules, as compared to the control group. On the average, the T3 production rates were increased more significantly than the corresponding circulating levels of the hormone, therefore, suggesting that the significant TSH inhibition observed in the euthyroid patients with autonomous thyroid nodules could be related with an increased peripheral utilization of triiodothyronine.
R Bianchi, and
G C Zucchelli, and
D Giannessi, and
A Pilo, and
F Cazzuola, and
L Del Corso, and
N Molea, and
A Carpi, and
M G Toni, and
G Mariani
January 1986,
Acta medica Iugoslavica,
R Bianchi, and
G C Zucchelli, and
D Giannessi, and
A Pilo, and
F Cazzuola, and
L Del Corso, and
N Molea, and
A Carpi, and
M G Toni, and
G Mariani
January 1986,
Acta medica Iugoslavica,
R Bianchi, and
G C Zucchelli, and
D Giannessi, and
A Pilo, and
F Cazzuola, and
L Del Corso, and
N Molea, and
A Carpi, and
M G Toni, and
G Mariani
April 1974,
Clinical endocrinology,
R Bianchi, and
G C Zucchelli, and
D Giannessi, and
A Pilo, and
F Cazzuola, and
L Del Corso, and
N Molea, and
A Carpi, and
M G Toni, and
G Mariani
October 1971,
The Journal of clinical endocrinology and metabolism,
R Bianchi, and
G C Zucchelli, and
D Giannessi, and
A Pilo, and
F Cazzuola, and
L Del Corso, and
N Molea, and
A Carpi, and
M G Toni, and
G Mariani
July 1973,
La Nouvelle presse medicale,
R Bianchi, and
G C Zucchelli, and
D Giannessi, and
A Pilo, and
F Cazzuola, and
L Del Corso, and
N Molea, and
A Carpi, and
M G Toni, and
G Mariani
May 1975,
Clinical endocrinology,
R Bianchi, and
G C Zucchelli, and
D Giannessi, and
A Pilo, and
F Cazzuola, and
L Del Corso, and
N Molea, and
A Carpi, and
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G Mariani
February 1984,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
R Bianchi, and
G C Zucchelli, and
D Giannessi, and
A Pilo, and
F Cazzuola, and
L Del Corso, and
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A Carpi, and
M G Toni, and
G Mariani
October 1979,
Clinical endocrinology,
R Bianchi, and
G C Zucchelli, and
D Giannessi, and
A Pilo, and
F Cazzuola, and
L Del Corso, and
N Molea, and
A Carpi, and
M G Toni, and
G Mariani
October 1984,
Clinical endocrinology,
R Bianchi, and
G C Zucchelli, and
D Giannessi, and
A Pilo, and
F Cazzuola, and
L Del Corso, and
N Molea, and
A Carpi, and
M G Toni, and
G Mariani
July 1988,
The American surgeon,
