Deep femoral and pelvic phlebothrombosis represents a safe indication for thrombolytic therapy, despite the fact that additionally considered surgical measures have increasingly been brought up for discussion very recently. While numerous studies are being considered for treatment with streptokinase, only sporadically does one hear of reports about therapy using Urokinase. In the case of a deep pelvo-femoral phlebothrombosis we decided to carry out thrombolytic treatment using Urokinase, the originally planned streptokinase treatment having had to be terminated owing to an allergic reaction.