-transparent.png){kind=logo}
OBJECTIVE To assess the source of maternal serum CA 125 during the first trimester of pregnancy. METHODS CA 125 was measured in stored samples from nonviable pregnancies of 8-13 weeks gestation. The study group comprised 19 women with vaginal bleeding and 13 non-bleeders. Only patients in whom chromosome analysis of the products of conception demonstrated a normal caryotype were included. CA 125 levels were expressed in multiples of the median (MoM) for normal pregnancies of the same gestational age. RESULTS Median MoM values of CA 125 were significantly higher in women with vaginal bleeding (1.81 MoM) as compared both to non-bleeders (0.82 MoM; p < 0.01-Mann-Whitney U-test) and to the normal pregnancies (1.01 MoM; p < 0.05). No significant difference was found between non-bleeding women and controls. CONCLUSIONS The present study indicates that in non-viable pregnancies with euploid fetuses an increase in maternal serum CA 125 levels was found only in presence of decidual disruption associated to vaginal bleeding. These findings are compatible with a prevalent decidual source of this antigen.
I Noci, and
R Biagiotti, and
E Periti, and
D Baronci, and
F Torricelli, and
L Cefalà, and
F Branconi, and
P Borri
June 1995,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
I Noci, and
R Biagiotti, and
E Periti, and
D Baronci, and
F Torricelli, and
L Cefalà, and
F Branconi, and
P Borri
January 2000,
Zentralblatt fur Gynakologie,
I Noci, and
R Biagiotti, and
E Periti, and
D Baronci, and
F Torricelli, and
L Cefalà, and
F Branconi, and
P Borri
February 1995,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
I Noci, and
R Biagiotti, and
E Periti, and
D Baronci, and
F Torricelli, and
L Cefalà, and
F Branconi, and
P Borri
January 1986,
Acta obstetricia et gynecologica Scandinavica,
I Noci, and
R Biagiotti, and
E Periti, and
D Baronci, and
F Torricelli, and
L Cefalà, and
F Branconi, and
P Borri
February 1995,
American journal of obstetrics and gynecology,
I Noci, and
R Biagiotti, and
E Periti, and
D Baronci, and
F Torricelli, and
L Cefalà, and
F Branconi, and
P Borri
January 1997,
Minerva ginecologica,
I Noci, and
R Biagiotti, and
E Periti, and
D Baronci, and
F Torricelli, and
L Cefalà, and
F Branconi, and
P Borri
November 1997,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
I Noci, and
R Biagiotti, and
E Periti, and
D Baronci, and
F Torricelli, and
L Cefalà, and
F Branconi, and
P Borri
February 1990,
Early human development,
I Noci, and
R Biagiotti, and
E Periti, and
D Baronci, and
F Torricelli, and
L Cefalà, and
F Branconi, and
P Borri
March 1990,
American journal of obstetrics and gynecology,
I Noci, and
R Biagiotti, and
E Periti, and
D Baronci, and
F Torricelli, and
L Cefalà, and
F Branconi, and
P Borri
November 1990,
Obstetrics and gynecology,
