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The aim of this study was to determine the distribution of ET-1 levels in the term maternal-fetal dyad. We also compared the levels of ET-1 between umbilical vessels and assessed the effect of labor on the concentration of ET-1. The ET-1 levels were measured in plasma from 18 term maternal-infant pairs. Amniotic fluid ET-1 levels were also measured in 9 of these pregnancies. The ET-1 levels were determined by radioimmunoassay (RIA) after extraction of plasma using Sep-Pak C18 cartridges. There were no significant differences in the ET-1 levels between the umbilical artery and vein. However, there were significant differences in the umbilical artery concentration in women who labored when compared with those delivered without labor (6.0 +/- 1.1 vs. 2.7 +/- 0.7 pg/ml; t test, p = 0.022). ET-1 levels were lowest in the maternal plasma (0.9 +/- 0.2 pg/ml) and highest in the amniotic fluid (83 +/- 15 pg/ml). Assuming that elevated plasma ET-1 levels reflect increased bioactivity, the higher mean ET-1 levels in the cord vessels and in the amniotic fluid when compared to maternal levels suggest a role for ET-1 in the regulation of the fetoplacental circulation and in the constriction of blood vessels in the uterus after parturition. The higher levels of ET-1 in the umbilical artery of women who underwent labor implies that ET-1 is released as a result of the stress of labor.
L A Bracero, and
M R Reale, and
M N Te, and
G A Zeballos, and
H S Dweck
October 2023,
NeoReviews,
L A Bracero, and
M R Reale, and
M N Te, and
G A Zeballos, and
H S Dweck
April 1990,
Bailliere's clinical rheumatology,
L A Bracero, and
M R Reale, and
M N Te, and
G A Zeballos, and
H S Dweck
January 1996,
Gynecologic and obstetric investigation,
L A Bracero, and
M R Reale, and
M N Te, and
G A Zeballos, and
H S Dweck
January 1995,
American journal of obstetrics and gynecology,
L A Bracero, and
M R Reale, and
M N Te, and
G A Zeballos, and
H S Dweck
January 2007,
Journal of endocrinological investigation,
L A Bracero, and
M R Reale, and
M N Te, and
G A Zeballos, and
H S Dweck
January 1995,
Gynecologic and obstetric investigation,
L A Bracero, and
M R Reale, and
M N Te, and
G A Zeballos, and
H S Dweck
January 1992,
The Hastings Center report,
L A Bracero, and
M R Reale, and
M N Te, and
G A Zeballos, and
H S Dweck
January 1986,
Springer seminars in immunopathology,
L A Bracero, and
M R Reale, and
M N Te, and
G A Zeballos, and
H S Dweck
January 1990,
Life sciences,
L A Bracero, and
M R Reale, and
M N Te, and
G A Zeballos, and
H S Dweck
January 2021,
Revista da Escola de Enfermagem da U S P,
