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The mechanisms by which tumor necrosis factor (TNF) exerts its necrotic effects are somewhat obscure. We hypothesize that TNF, by monocyte activation, produces the procoagulant tissue factor, thus leading to a state of hypercoagulability with resultant thrombotic vascular occlusion and tissue necrosis. To test this hypothesis, modified recalcification time values (in minutes +/- standard deviation) were obtained on aliquots of blood with A) 20 microL of albumin, B) 20 microL of saline containing endotoxin, and C) 20 microL of albumin with 450 units of TNF. No differences were noted if the samples were not incubated. We conclude that TNF, can cause tumor (tissue) necrosis, and since incubation is required, TNF alone (without monocyte activation) has no procoagulant activity.
C R Spillert, and
S Sun, and
R Ponnudurai, and
M A Miller, and
E J Lazaro
January 1988,
Natural immunity and cell growth regulation,
C R Spillert, and
S Sun, and
R Ponnudurai, and
M A Miller, and
E J Lazaro
November 1986,
Cancer research,
C R Spillert, and
S Sun, and
R Ponnudurai, and
M A Miller, and
E J Lazaro
May 1987,
Cancer research,
C R Spillert, and
S Sun, and
R Ponnudurai, and
M A Miller, and
E J Lazaro
October 1987,
Cellular immunology,
C R Spillert, and
S Sun, and
R Ponnudurai, and
M A Miller, and
E J Lazaro
April 1999,
The Journal of experimental medicine,
C R Spillert, and
S Sun, and
R Ponnudurai, and
M A Miller, and
E J Lazaro
January 2007,
Nutrition research and practice,
C R Spillert, and
S Sun, and
R Ponnudurai, and
M A Miller, and
E J Lazaro
January 1989,
International archives of allergy and applied immunology,
C R Spillert, and
S Sun, and
R Ponnudurai, and
M A Miller, and
E J Lazaro
January 1992,
Journal of immunology (Baltimore, Md. : 1950),
C R Spillert, and
S Sun, and
R Ponnudurai, and
M A Miller, and
E J Lazaro
August 1997,
Zhonghua nei ke za zhi,
C R Spillert, and
S Sun, and
R Ponnudurai, and
M A Miller, and
E J Lazaro
December 2009,
Arteriosclerosis, thrombosis, and vascular biology,
