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Noradrenergic pathways in the brain have been thought to be related to the site of anesthetic action. Norepinephrine (NE) in the central nervous system stimulates phosphatidylinositol (PI) turnover through alpha 1-adrenergic receptors. The present study was designed to examine the effects of intravenous anesthetics on NE-induced PI turnover in rat cerebral cortical prisms. NE-induced inositol monophosphate (IP1) formation was inhibited by droperidol (dose for 50% inhibition [ID50], 0.0258 +/- 0.00023 microM [mean +/- SE]), fentanyl (2.36 +/- 0.0017), diazepam (201 +/- 2.12), and thiamylal (231 +/- 1.94) in a dose-dependent manner, but was not affected by ketamine. Naloxone or flumazenil did not attenuate the inhibitory effect of fentanyl or diazepam on NE-induced IP1 formation. The results suggest that these effects on the PI turnover in the cortex may be related to their pharmacologic properties including the anesthetic action.
T Makita, and
O Shibata, and
T Tsujita, and
T Fujigaki, and
H Nakamura, and
K Sumikawa
October 1998,
Anesthesiology,
T Makita, and
O Shibata, and
T Tsujita, and
T Fujigaki, and
H Nakamura, and
K Sumikawa
October 1983,
Journal of neurochemistry,
T Makita, and
O Shibata, and
T Tsujita, and
T Fujigaki, and
H Nakamura, and
K Sumikawa
January 1994,
Klinische Anasthesiologie und Intensivtherapie,
T Makita, and
O Shibata, and
T Tsujita, and
T Fujigaki, and
H Nakamura, and
K Sumikawa
September 1986,
Japanese journal of pharmacology,
T Makita, and
O Shibata, and
T Tsujita, and
T Fujigaki, and
H Nakamura, and
K Sumikawa
November 1973,
Anesthesiology,
T Makita, and
O Shibata, and
T Tsujita, and
T Fujigaki, and
H Nakamura, and
K Sumikawa
April 1972,
The Biochemical journal,
T Makita, and
O Shibata, and
T Tsujita, and
T Fujigaki, and
H Nakamura, and
K Sumikawa
February 1976,
Archives internationales de pharmacodynamie et de therapie,
T Makita, and
O Shibata, and
T Tsujita, and
T Fujigaki, and
H Nakamura, and
K Sumikawa
October 1982,
Pharmacology, biochemistry, and behavior,
T Makita, and
O Shibata, and
T Tsujita, and
T Fujigaki, and
H Nakamura, and
K Sumikawa
January 1989,
Life sciences,
T Makita, and
O Shibata, and
T Tsujita, and
T Fujigaki, and
H Nakamura, and
K Sumikawa
January 1982,
Proceedings of the Western Pharmacology Society,
