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In this experiment, the model of experimental atherosclerosis in rabbits was established by feeding the cholesterol contained food for 12 weeks. The effect of Xueguantong (XGT) in inhibiting atherosclerotic formation in rabbits has been studied. It was found that XGT could decrease serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), platelet aggregation and platelet adhesion. The aortic atherosclerotic plaque intimal coverage and ratio of atherosclerotic plaque of aortic intimal coverage to aortic medium coverage in XGT groups were significantly smaller than that in the model group (P < 0.05). The results showed that XGT could inhibit experimental atherosclerotic formation in rabbits, it might be relevant to that XGT could reduce the TC and inhibit platelet aggregation.
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