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1. The caudal pressor area (CPA) is a recently identified site within the ventrolateral medulla which is involved in cardiovascular regulation. CPA chemical stimulation by L-glutamate produces an increase in arterial blood pressure (ABP) while its inhibition by GABA or glycine evokes marked hypotension. In the present study, we sought to determine the potential neural pathways underlying these responses. 2. In urethane-anesthetized, paralyzed, artificially ventilated rats, CPA inhibition by bilateral microinjection of the inhibitory amino acid glycine (Gly, 100 nmol 200 nl-1 site-1) produced an average decrease of -38 +/- 4.3 mmHg in ABP (N = 6). Ten min after bilateral microinjection of the broad-spectrum glutamate antagonist kynurenic acid (KYN, 2 nmol 200 nl-1 site-1) into the caudal ventrolateral medulla (CVLM) depressor responses to CPA inhibition were virtually abolished (-3 +/- 1.7 mmHg, P < 0.05). Similar microinjection of KYN into the rostral ventrolateral medulla (RVLM) or into the CPA itself did not modify depressor responses to CPA inhibition by glycine. 3. CPA stimulation by bilateral microinjection of the excitatory amino acid L-glutamate (L-glu, 50 nmol 200 nl-1 site-1) produced an increase in ABP (+43 +/- 5.4 mmHg, N = 6). Bilateral microinjection of the GABAA antagonist bicuculline methiodide (BIC, 200 pmol 200 nl-1 site-1) into the CVLM markedly reduced pressor responses to CPA stimulation (+6 +/- 2.7 mmHg, P < 0.05). Similar application of BIC into the RVLM or CPA did not modify pressor responses to CPA stimulation by glutamic acid.
R R Campos Júnior, and
O S Possas, and
S L Cravo, and
O U Lopes, and
P G Guertzenstein
March 2011,
Neuroscience,
R R Campos Júnior, and
O S Possas, and
S L Cravo, and
O U Lopes, and
P G Guertzenstein
August 2007,
Brain research,
R R Campos Júnior, and
O S Possas, and
S L Cravo, and
O U Lopes, and
P G Guertzenstein
February 2005,
The Journal of comparative neurology,
R R Campos Júnior, and
O S Possas, and
S L Cravo, and
O U Lopes, and
P G Guertzenstein
August 2000,
American journal of physiology. Regulatory, integrative and comparative physiology,
R R Campos Júnior, and
O S Possas, and
S L Cravo, and
O U Lopes, and
P G Guertzenstein
August 1996,
Sheng li xue bao : [Acta physiologica Sinica],
R R Campos Júnior, and
O S Possas, and
S L Cravo, and
O U Lopes, and
P G Guertzenstein
August 2008,
Brain research,
R R Campos Júnior, and
O S Possas, and
S L Cravo, and
O U Lopes, and
P G Guertzenstein
December 2001,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
R R Campos Júnior, and
O S Possas, and
S L Cravo, and
O U Lopes, and
P G Guertzenstein
August 2001,
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
R R Campos Júnior, and
O S Possas, and
S L Cravo, and
O U Lopes, and
P G Guertzenstein
August 1988,
Brain research,
R R Campos Júnior, and
O S Possas, and
S L Cravo, and
O U Lopes, and
P G Guertzenstein
October 2012,
Cellular and molecular neurobiology,
