-transparent.png){kind=logo}
Earlier in vivo experiments suggest that serotonin1A (5-HT1A) agonists are new tools for the treatment of experimental cerebral ischemia. The present study examined this idea in an in vitro system. Incubation of rat brain slices under anoxic conditions for 30 min decreased protein synthesis that was assayed in a normoxic medium by measuring the incorporation of [14C]lysine into trichloroacetic acid-insoluble tissue extracts. The 5-HT1A agonists 8-hydroxy-2-(di-n-propylamino) tetralin (10-100 microM) and buspirone (50 microM) attenuated the anoxia-induced decrease in protein synthesis in the slices. Although the degree of the effect is small, it may be relevant to the neuroprotective effect in the in vivo experiments.
M Suzuki, and
T Matsuda, and
P Somboonthum, and
S Asano, and
K Takuma, and
H Nogi, and
A Baba
September 1991,
Journal of neurochemistry,
M Suzuki, and
T Matsuda, and
P Somboonthum, and
S Asano, and
K Takuma, and
H Nogi, and
A Baba
May 1987,
Journal of neurochemistry,
M Suzuki, and
T Matsuda, and
P Somboonthum, and
S Asano, and
K Takuma, and
H Nogi, and
A Baba
February 1979,
Brain research,
M Suzuki, and
T Matsuda, and
P Somboonthum, and
S Asano, and
K Takuma, and
H Nogi, and
A Baba
May 1976,
Circulation research,
M Suzuki, and
T Matsuda, and
P Somboonthum, and
S Asano, and
K Takuma, and
H Nogi, and
A Baba
May 1974,
Journal of neurochemistry,
M Suzuki, and
T Matsuda, and
P Somboonthum, and
S Asano, and
K Takuma, and
H Nogi, and
A Baba
March 1984,
Journal of neurochemistry,
M Suzuki, and
T Matsuda, and
P Somboonthum, and
S Asano, and
K Takuma, and
H Nogi, and
A Baba
October 2010,
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine,
M Suzuki, and
T Matsuda, and
P Somboonthum, and
S Asano, and
K Takuma, and
H Nogi, and
A Baba
January 1979,
Developmental neuroscience,
M Suzuki, and
T Matsuda, and
P Somboonthum, and
S Asano, and
K Takuma, and
H Nogi, and
A Baba
March 1984,
Brain research,
M Suzuki, and
T Matsuda, and
P Somboonthum, and
S Asano, and
K Takuma, and
H Nogi, and
A Baba
December 1975,
Brain research,
