-transparent.png){kind=logo}
Development of tolerance to the hypotensive effects of clonidine was investigated in spontaneously hypertensive rats (SHR). Clonidine (125 micrograms/kg/day) was administered subcutaneously for 5 weeks using an osmotic infusion pump. During the whole infusion period, significant hypotensive and bradycardiac effects were observed. Plasma clonidine concentrations were maintained relatively constant at about 2 ng/ml during the infusion period. On termination of treatment with clonidine, both the blood pressure and heart rate rapidly recovered to the control levels. These findings suggest that clonidine does not cause tolerance to its hypotensive effects in SHR with the present administration regimen.
T Naruse, and
R Ishii, and
T Tagawa
December 1994,
Hypertension (Dallas, Tex. : 1979),
T Naruse, and
R Ishii, and
T Tagawa
October 1983,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
T Naruse, and
R Ishii, and
T Tagawa
June 1980,
The Journal of pharmacology and experimental therapeutics,
T Naruse, and
R Ishii, and
T Tagawa
January 1994,
Masui. The Japanese journal of anesthesiology,
T Naruse, and
R Ishii, and
T Tagawa
November 1989,
Hypertension (Dallas, Tex. : 1979),
T Naruse, and
R Ishii, and
T Tagawa
November 2001,
American journal of hypertension,
T Naruse, and
R Ishii, and
T Tagawa
December 1980,
Clinical science (London, England : 1979),
T Naruse, and
R Ishii, and
T Tagawa
January 1978,
Jikken dobutsu. Experimental animals,
T Naruse, and
R Ishii, and
T Tagawa
January 1983,
Clinical and experimental hypertension. Part A, Theory and practice,
T Naruse, and
R Ishii, and
T Tagawa
March 1977,
Archives internationales de pharmacodynamie et de therapie,
