Biomaterial Database

Interactions between food components and drugs. Part 3. Interactions between pectin and propranolol. 1995

R Neubert, and B Fritsch, and G Dongowski

College of Pharmacy, Martin-Luther-University, Halle, Saale.

Bioavailability of drugs can be affected distinctly by interactions with food components. Effects of structural parameters of the soluble dietary fiber pectin on lipid-membrane transport of propranolol (1) was investigated in vitro using a two-compartment model with a dodecanol-collodium membrane at pH 7.2 and 37 degrees C. Starting from practically fully esterified citrus pectin two series of defined and in their structural parameters gradually varied pectins were prepared. In presence of pectins with a blockwise distribution of free COOH-groups the portion of permeated 1 is significantly diminished with a decreasing degree of esterification (DE). On the other hand, only in the smallest DE pectins having statistically distributed free COOH-groups seemed to affect the transport rate of 1. The viscosity of the tested pectins possessed no significant influence on the passage of 1.

UI	MeSH Term	Description	Entries
D010368	Pectins	High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.	Calcium Pectinate,Methoxy Pectin,Methoxylpectin,Methoxypectin,Pectin,Pectinic Acid,Zinc Pectinate,Pectin, Methoxy,Pectinate, Calcium,Pectinate, Zinc
D010539	Permeability	Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.	Permeabilities
D011433	Propranolol	A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.	Dexpropranolol,AY-20694,Anaprilin,Anapriline,Avlocardyl,Betadren,Dociton,Inderal,Obsidan,Obzidan,Propanolol,Propranolol Hydrochloride,Rexigen,AY 20694,AY20694,Hydrochloride, Propranolol
D001682	Biological Availability	The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.	Availability Equivalency,Bioavailability,Physiologic Availability,Availability, Biologic,Availability, Biological,Availability, Physiologic,Biologic Availability,Availabilities, Biologic,Availabilities, Biological,Availabilities, Physiologic,Availability Equivalencies,Bioavailabilities,Biologic Availabilities,Biological Availabilities,Equivalencies, Availability,Equivalency, Availability,Physiologic Availabilities
D013329	Structure-Activity Relationship	The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.	Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D014783	Viscosity	The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Viscosities
D018565	Food-Drug Interactions	The pharmacological result, either desirable or undesirable, of drugs interacting with components of the diet. (From Stedman, 25th ed)	Drug-Food Interactions,Food Interactions,Drug Food Interactions,Drug-Food Interaction,Food Drug Interactions,Food Interaction,Food-Drug Interaction,Interaction, Drug-Food,Interaction, Food,Interaction, Food-Drug,Interactions, Drug-Food,Interactions, Food,Interactions, Food-Drug