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Of 180 patients with coronary heart disease (CHD) 43 (23.9%) showed in microthrombi conjunctival microcirculation. We compared the healthy subjects with the patients with microthrombi and thrombi-free as well as with the patients with microthrombi pre- and post-treatment of heparin or salvia miltiorrhizae. The formation and the number of microthrombi in the CHD patients were closely related to symptoms, ECGS, plasma TXB2, 6-kero-PGF1a and other indexes on hemodynamics. Follow-up of the patients with microthrombi revealed that their death rate was higher than that of CHD patients without microthrombi, especially in the sudden deaths. We consider that microthrombi may be regarded as an important index of the state, therapeutic efficacy, and prognosis of the CHD patients. The use of heparin may certainly be based on the condition of the microthrombi in the microcirculation of CHD patients.
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