Biomaterial Database

[Establishment and characteristics of a model of nude mouse xenograft of human retinoblastoma]. 1995

X Yi, and Z Ni, and W Wang

Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical University.

The authors reported the establishment and biological characteristics of a model of nude mouse xenograft of human retinoblastoma (RB). Immediately after the enucleation of the human globe with RB, the tumor tissue was transplanted subcutaneously into a nude mouse. The tumor grew constantly and was passaged serially for 14 passages till now. The results of the following examinations of the xenograft and primary tumor were compared: light and electron microscopy, immunohistochemistry, flow cytometry and chromosome analysis. The comparisons reveal that the main biological characteristics of the xenograft model are consistent with those of the primary tumor and also maintain throughout the serial passages. The model can be used for further laboratory studies.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008807	Mice, Inbred BALB C	An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.	BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008819	Mice, Nude	Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.	Athymic Mice,Mice, Athymic,Nude Mice,Mouse, Athymic,Mouse, Nude,Athymic Mouse,Nude Mouse
D009368	Neoplasm Transplantation	Experimental transplantation of neoplasms in laboratory animals for research purposes.	Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005134	Eye Neoplasms	Tumors or cancer of the EYE.	Cancer of Eye,Eye Cancer,Cancer of the Eye,Neoplasms, Eye,Cancer, Eye,Cancers, Eye,Eye Cancers,Eye Neoplasm,Neoplasm, Eye
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia