Biomaterial Database

Functional characterization of peripheral blood neutrophils in patients with hyperthyroidism. 1995

A Hrycek

Second Department of Internal Diseases, Silesian Medical Academy, Katowice, Poland.

The thyroid hormones may exert an important effect on neutrophil functions which play a key role in the defence against microbial pathogens. Therefore investigations of the biological functions of neutrophils in peripheral blood of 80 women with hyperthyroidism were performed. The following functions of neutrophils were examined: nitroblue tetrazolium (NBT) reduction ability, phagocytosis, adherence to fibers as well as spontaneous migration of leukocytes and activity of lysozyme in serum. The total number of leukocytes and neutrophils was also determined. The results were compared with those in the control group consisting of 40 healthy women. The data show that in patients with hyperthyroidism, the number of leukocytes and neutrophils was decreased (respectively 4.90 x 10(9) +/- 1.20, 2.70 x 10(9) +/- 0.54 in patients, and 5.40 x 10(9) +/- 1.30, 3.00 x 10(9) +/- 0.74 in the control subjects), index of spontaneous reduction NBT was increased (17.1% +/- 4.5 in patients and 11.1% +/- 4.5 in the control group), index of phagocytosing cells was decreased (63.0% +/- 16.0, 80.3% +/- 14.0 in patients and 72.2% +/- 12.1, 87.4% +/- 12.0 in the control group), an increase in adherence (71% +/- 17 in patients and 58% +/- 10 in the control subjects), and a decrease in the lysozyme activity in undiluted and diluted serum was found (185 IU/ml +/- 85,209 IU/ml +/- 78 in patients and 284 IU/ml +/- 84,352 IU/ml +/- 140 in the control group).

UI	MeSH Term	Description	Entries
D006980	Hyperthyroidism	Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.	Hyperthyroid,Primary Hyperthyroidism,Hyperthyroidism, Primary,Hyperthyroids
D007958	Leukocyte Count	The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.	Blood Cell Count, White,Differential Leukocyte Count,Leukocyte Count, Differential,Leukocyte Number,White Blood Cell Count,Count, Differential Leukocyte,Count, Leukocyte,Counts, Differential Leukocyte,Counts, Leukocyte,Differential Leukocyte Counts,Leukocyte Counts,Leukocyte Counts, Differential,Leukocyte Numbers,Number, Leukocyte,Numbers, Leukocyte
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009113	Muramidase	A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.	Lysozyme,Leftose,N-Acetylmuramide Glycanhydrolase,Glycanhydrolase, N-Acetylmuramide,N Acetylmuramide Glycanhydrolase
D009504	Neutrophils	Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.	LE Cells,Leukocytes, Polymorphonuclear,Polymorphonuclear Leukocytes,Polymorphonuclear Neutrophils,Neutrophil Band Cells,Band Cell, Neutrophil,Cell, LE,LE Cell,Leukocyte, Polymorphonuclear,Neutrophil,Neutrophil Band Cell,Neutrophil, Polymorphonuclear,Polymorphonuclear Leukocyte,Polymorphonuclear Neutrophil
D009580	Nitroblue Tetrazolium	Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases, the latter causing neutrophils to reduce the dye; used to confirm diagnosis of chronic granulomatous disease.	Nitro-BT,Nitrotetrazolium Blue,Tetrazolium Nitroblue,Blue, Nitrotetrazolium,Nitroblue, Tetrazolium,Tetrazolium, Nitroblue
D010587	Phagocytosis	The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).	Phagocytoses
D002448	Cell Adhesion	Adherence of cells to surfaces or to other cells.	Adhesion, Cell,Adhesions, Cell,Cell Adhesions
D002465	Cell Movement	The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.	Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D005260	Female		Females