BIOMAT Database Logo BIOMAT Database Logo

A cytogenetic study in women who had used oral contraceptives and in their progeny. 1975

N Bishun, and J Mills, and J V Parke, and D C Williams

A study has been made of the chromosome numbers and characteristics of leucocytes cultured from mothers (a total of 77) who had taken one or more types of oral contraceptive, and their babies (108), and compared with similar numbers of control subjects. When the total cytogenetic results from test and control mothers were compared, no significant differences in frequency or type of chromosome abnormalities was observed. However, with certain types of oral contraceptive, minor differences in the numbers of chromosome abnormalities were found between test and control groups and the significance of these findings are discussed. The only significant abnormalities observed in the babies from mothers taking oral contraceptives were slight increases in the numbers who had cells with less than 46 chromosomes and who exhibited chromosomal gaps. The number of abnormal cells was significantly higher in babies born to mothers who had been taking norethynodrel (Conovid) (4.6% abnormal cells in test babies; 2.0% in controls).

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007621 Karyotyping Mapping of the KARYOTYPE of a cell. Karyotype Analysis Methods,Analysis Method, Karyotype,Analysis Methods, Karyotype,Karyotype Analysis Method,Karyotypings,Method, Karyotype Analysis,Methods, Karyotype Analysis
D007962 Leukocytes White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES). Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D009641 Norethynodrel A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and ENDOMETRIOSIS. As a contraceptive (CONTRACEPTIVE AGENTS), it has usually been administered in combination with MESTRANOL. 19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-, (17alpha)-,Norethynodrel, (8 alpha)-(+-)-Isomer
D011003 Ploidies The degree of replication of the chromosome set in the karyotype. Ploidy
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D002872 Chromosome Deletion Actual loss of portion of a chromosome. Monosomy, Partial,Partial Monosomy,Deletion, Chromosome,Deletions, Chromosome,Monosomies, Partial,Partial Monosomies
D002986 Clinical Trials as Topic Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. Clinical Trial as Topic

Related Publications

N Bishun, and J Mills, and J V Parke, and D C Williams
Cytogenetic study of blood in women who had used oral contraceptives.
January 1990, Neoplasma,
N Bishun, and J Mills, and J V Parke, and D C Williams
Cytogenetic studies on women using oral contraceptives and their progeny.
October 1970, American journal of obstetrics and gynecology,
N Bishun, and J Mills, and J V Parke, and D C Williams
Chlamydia trachomatis in patients who used oral contraceptives and had intermenstrual spotting.
May 1993, Obstetrics and gynecology,
N Bishun, and J Mills, and J V Parke, and D C Williams
Carbohydrate metabolism in women who used oral contraceptives containing levonorgestrel or desogestrel: a 6-month prospective study.
May 1986, Fertility and sterility,
N Bishun, and J Mills, and J V Parke, and D C Williams
Genitourinary infection prevalence among women who used an intrauterine device or oral contraceptives.
October 2013, Archives of gynecology and obstetrics,
N Bishun, and J Mills, and J V Parke, and D C Williams
Nutrient intakes of women who use oral contraceptives.
September 1991, Journal of the American Dietetic Association,
N Bishun, and J Mills, and J V Parke, and D C Williams
Use of oral contraceptives by women who smoke.
June 1999, American journal of obstetrics and gynecology,
N Bishun, and J Mills, and J V Parke, and D C Williams
Oral contraceptives and in vivo cytogenetic studies.
February 1972, Obstetrics and gynecology,
N Bishun, and J Mills, and J V Parke, and D C Williams
Types of combined oral contraceptives used by US women.
December 2012, Contraception,
N Bishun, and J Mills, and J V Parke, and D C Williams
Types of combined oral contraceptives used by US women.
July 2013, Contraception,
Copied contents to your clipboard!