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The concentrations of fluconazole, a systemic antifungal agent, were determined in the split ejaculate of seven healthy volunteers. Following once-daily oral administration of fluconazole 200 mg over a period of 5 days, the fluconazole levels were determined in ejaculate samples which had been divided into two consecutive fractions upon collection. Simultaneously, a blood sample was drawn for the determination of fluconazole serum levels. It was shown that the fluconazole concentrations determined in both ejaculate fractions corresponded to those found in the serum. As the first fraction of the ejaculate originates in the prostate, the prostatic fluconazole concentrations are likely to be similar to the fluconazole levels found in th ejaculate.
P Schramm, and
A Wildfeuer, and
E Sarnow
January 1993,
Infection,
P Schramm, and
A Wildfeuer, and
E Sarnow
February 1979,
International journal of clinical pharmacology and biopharmacy,
P Schramm, and
A Wildfeuer, and
E Sarnow
November 1980,
Urology,
P Schramm, and
A Wildfeuer, and
E Sarnow
January 1991,
Infection,
P Schramm, and
A Wildfeuer, and
E Sarnow
January 1994,
Journal of pharmaceutical and biomedical analysis,
P Schramm, and
A Wildfeuer, and
E Sarnow
November 1993,
The Journal of urology,
P Schramm, and
A Wildfeuer, and
E Sarnow
March 2010,
Science (New York, N.Y.),
P Schramm, and
A Wildfeuer, and
E Sarnow
March 1975,
Journal of reproduction and fertility,
P Schramm, and
A Wildfeuer, and
E Sarnow
January 1981,
Progress in clinical and biological research,
P Schramm, and
A Wildfeuer, and
E Sarnow
January 1954,
Zeitschrift fur Urologie,
