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The mechanism of DDAVP's shortening of acetylsalicylic acid (ASA) prolonged bleeding times was investigated. Sixteen healthy subjects received two dosages of ASA (100 mg) in 12 hours. Twenty four hours after the first ASA application and again after 32 hours DDAVP was administered intravenously (0.4 micrograms/kg). The trial was terminated after 48 hrs. In between, blood samples were drawn and analyzed for the in vivo bleeding time (Simplate time), in vitro bleeding test (IVBT, Thrombostat 4000), von Willebrand factor antigen (vWf:Ag), Ristocetin cofactor activity (vWf R:Co), plasma beta-thromboglobulin (beta-TG), platelet ATP/ADP, platelet aggregation (collagen, ADP, arachidonic acid), and plasma and platelet thromboxane levels. Simplate time (BT) and IVBT showed an excellent inverse correlation with vWf R:Co (r2 BT = 0.97 and r2 IVBT = 0.99, respectively) during the time when DDAVP was administered, suggesting the involvement of plasma vWF in DDAVP's shortening of the bleeding time. The involvement of plasma thromboxane in this mechanism could be excluded. In addition, DDAVP hampered platelet aggregation tests, possibly due to the inhibition of the release reaction (reduced beta-TG in plasma) by a direct interaction with platelets.
K H Beck, and
P Mohr, and
U Bleckmann, and
H Schweer, and
V Kretschmer
June 1986,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
K H Beck, and
P Mohr, and
U Bleckmann, and
H Schweer, and
V Kretschmer
April 1987,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
K H Beck, and
P Mohr, and
U Bleckmann, and
H Schweer, and
V Kretschmer
November 1975,
Thrombosis et diathesis haemorrhagica,
K H Beck, and
P Mohr, and
U Bleckmann, and
H Schweer, and
V Kretschmer
November 1974,
Acta paediatrica Scandinavica,
K H Beck, and
P Mohr, and
U Bleckmann, and
H Schweer, and
V Kretschmer
February 1970,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K H Beck, and
P Mohr, and
U Bleckmann, and
H Schweer, and
V Kretschmer
October 1971,
Helvetica paediatrica acta,
K H Beck, and
P Mohr, and
U Bleckmann, and
H Schweer, and
V Kretschmer
August 2003,
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
K H Beck, and
P Mohr, and
U Bleckmann, and
H Schweer, and
V Kretschmer
August 1971,
Die Medizinische Welt,
K H Beck, and
P Mohr, and
U Bleckmann, and
H Schweer, and
V Kretschmer
September 2007,
Veterinary clinical pathology,
K H Beck, and
P Mohr, and
U Bleckmann, and
H Schweer, and
V Kretschmer
December 1975,
Klinische Wochenschrift,
