BIOMAT Database Logo BIOMAT Database Logo

Eosinophilia-myalgia syndrome: a long-term follow-up study. 1995

D S Campbell, and P D Morris, and R M Silver
Environmental Epidemiology Section, North Carolina Department of Environment, Health, and Natural Resources, Raleigh, USA.

In this case-series analysis, of 34 patients originally identified with eosinophilia-myalgia syndrome (EMS), 31 survivors were followed-up by yearly telephone interviews. We ascertained type, duration, and severity of symptoms and whether certain patient characteristics were associated with illness improvement. At a median of 3.6 years after onset, 3 patients (8.8%) had died. Two (5.9%) were well, 7 (20.6%) were improved, and 22 (64.7%) reported either no change or worsening overall condition compared to 1 year prior. Musculoskeletal and neurologic symptoms predominated. The prevalence of several symptoms, including muscle cramps, joint pain, and cognitive symptoms, increased over the course of study. Age, sex, peak eosinophil count, early prednisone use, and usual dose or duration of L-tryptophan use were not associated with significant improvement. We conclude that for the majority of patients, EMS is a chronic illness having a major impact on life-style 3.6 years after onset. The chronic, often worsening pattern of illness suggests an ongoing pathogenetic mechanism.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011795 Surveys and Questionnaires Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D016603 Eosinophilia-Myalgia Syndrome A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93) Eosinophilia-Myalgia Syndrome, L-Tryptophan-Related,L-Tryptophan-Related Eosinophilia-Myalgia Syndrome,Syndrome, Eosinophilia-Myalgia, L-Tryptophan-Related,Eosinophilia Myalgia Syndrome,Eosinophilia-Myalgia Syndromes,Eosinophilia-Myalgia Syndromes, L-Tryptophan-Related,L-Tryptophan-Related Eosinophilia-Myalgia Syndromes,Syndrome, Eosinophilia-Myalgia,Syndrome, L-Tryptophan-Related Eosinophilia-Myalgia,Syndromes, Eosinophilia-Myalgia,Syndromes, L-Tryptophan-Related Eosinophilia-Myalgia

Related Publications

D S Campbell, and P D Morris, and R M Silver
[Eosinophilia-myalgia syndrome. Clinical aspects and follow-up of 10 patients].
July 1992, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
D S Campbell, and P D Morris, and R M Silver
[The tryptophan-associated eosinophilia-myalgia syndrome. A clinical follow-up of 8 patients].
February 1993, Deutsche medizinische Wochenschrift (1946),
D S Campbell, and P D Morris, and R M Silver
Eosinophilia-myalgia syndrome: follow-up survey of patients--New York, 1990-1991.
June 1991, MMWR. Morbidity and mortality weekly report,
D S Campbell, and P D Morris, and R M Silver
Clinical follow-up and immunogenetic studies of 32 patients with eosinophilia-myalgia syndrome.
May 1991, Lancet (London, England),
D S Campbell, and P D Morris, and R M Silver
Eosinophilia-myalgia syndrome.
April 1992, International journal of dermatology,
D S Campbell, and P D Morris, and R M Silver
[Eosinophilia-myalgia syndrome].
July 1992, Nihon rinsho. Japanese journal of clinical medicine,
D S Campbell, and P D Morris, and R M Silver
Eosinophilia-myalgia syndrome.
April 1991, The Western journal of medicine,
D S Campbell, and P D Morris, and R M Silver
[Eosinophilia-myalgia syndrome].
June 1991, Der Nervenarzt,
D S Campbell, and P D Morris, and R M Silver
Eosinophilia myalgia syndrome.
July 1990, New York state journal of medicine,
D S Campbell, and P D Morris, and R M Silver
[Eosinophilia-myalgia syndrome].
March 1991, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
Copied contents to your clipboard!