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N-terminal peptides from the calpain small subunit were shown to have dose-dependent chemotactic activity toward several types of leukemia cells: T cell, B cell, monocyte and granulocyte/monocyte line leukemia cells. In order to prove that chemotaxis is mediated via receptors, a fluorescein-labeled probe was prepared from one of the N-terminal peptides and its interaction with peripheral leukocytes was estimated by means of flow cytometry, resulting in staining not only of neutrophils but also of most of the monocytes and more than half of the T and B lymphocytes. The results indicate that calpain-derived N-terminal peptides may be involved in defense mechanisms, inducing chemotaxis of immunocytes as well as that of neutrophils.
M Kunimatsu, and
X J Ma, and
Y Ozaki, and
M Narita, and
M Mizokami, and
M Sasaki
January 1985,
Survey of immunologic research,
M Kunimatsu, and
X J Ma, and
Y Ozaki, and
M Narita, and
M Mizokami, and
M Sasaki
August 1980,
FEBS letters,
M Kunimatsu, and
X J Ma, and
Y Ozaki, and
M Narita, and
M Mizokami, and
M Sasaki
January 1984,
Science (New York, N.Y.),
M Kunimatsu, and
X J Ma, and
Y Ozaki, and
M Narita, and
M Mizokami, and
M Sasaki
March 1989,
Science (New York, N.Y.),
M Kunimatsu, and
X J Ma, and
Y Ozaki, and
M Narita, and
M Mizokami, and
M Sasaki
April 2008,
The Journal of biological chemistry,
M Kunimatsu, and
X J Ma, and
Y Ozaki, and
M Narita, and
M Mizokami, and
M Sasaki
October 1983,
European journal of biochemistry,
M Kunimatsu, and
X J Ma, and
Y Ozaki, and
M Narita, and
M Mizokami, and
M Sasaki
March 1996,
Journal of medicinal chemistry,
M Kunimatsu, and
X J Ma, and
Y Ozaki, and
M Narita, and
M Mizokami, and
M Sasaki
October 1998,
Biochimica et biophysica acta,
M Kunimatsu, and
X J Ma, and
Y Ozaki, and
M Narita, and
M Mizokami, and
M Sasaki
January 1979,
Biochemical and biophysical research communications,
M Kunimatsu, and
X J Ma, and
Y Ozaki, and
M Narita, and
M Mizokami, and
M Sasaki
March 1968,
The Biochemical journal,
