Biomaterial Database

Single dose 6 Gy prophylaxis for heterotopic ossification after total hip arthroplasty. 1995

R J Fingeroth, and A Q Ahmed

Division of Orthopedic Surgery, Baystate Medical Center, Springfield, MA, USA.

Forty-five patients (50 hips) at risk for heterotopic ossification after total hip arthroplasty who received a single dose of 6 Gy postoperative irradiation were compared with a historical control group of 42 patients (50 hips) with similar risk factors who did not receive radiation prophylaxis. All surgeries were done by the same surgeon using the same perioperative protocol. Radiation was delivered through anteroposterior/posteroanterior limited fields, avoiding areas of desired bony ingrowth. Of those hips that received radiation, Grade II or III heterotopic bone developed in 6% and Grade IV heterotopic bone developed in none. Of the control group, Grade II or III heterotopic bone developed in 34% of the hips and Grade IV heterotopic bone in 6%. The radiated hips had a significant net gain in abduction and adduction when compared with the nonradiated hips. No early complications were noted in association with the radiation treatment. A single dose of 6 Gy of radiation given within the first 3 postoperative days provides effective prophylaxis against heterotopic ossification developing after total hip arthroplasty in high risk patients.

UI	MeSH Term	Description	Entries
D009999	Ossification, Heterotopic	The development of bony substance in normally soft structures.	Ossification, Pathologic,Ectopic Ossification,Heterotopic Ossification,Ossification, Ectopic,Ossification, Pathological,Pathologic Ossification,Pathological Ossification
D010003	Osteoarthritis	A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	Arthritis, Degenerative,Osteoarthrosis,Osteoarthrosis Deformans,Arthroses,Arthrosis,Arthritides, Degenerative,Degenerative Arthritides,Degenerative Arthritis,Osteoarthritides,Osteoarthroses
D011183	Postoperative Complications	Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D011829	Radiation Dosage	The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).	Sievert Units,Dosage, Radiation,Gray Units,Gy Radiation,Sv Radiation Dose Equivalent,Dosages, Radiation,Radiation Dosages,Units, Gray,Units, Sievert
D006622	Hip Prosthesis	Replacement for a hip joint.	Femoral Head Prosthesis,Femoral Head Prostheses,Hip Prostheses,Prostheses, Femoral Head,Prostheses, Hip,Prosthesis, Femoral Head,Prosthesis, Hip
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D012189	Retrospective Studies	Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.	Retrospective Study,Studies, Retrospective,Study, Retrospective
D016059	Range of Motion, Articular	The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.	Passive Range of Motion,Joint Flexibility,Joint Range of Motion,Range of Motion,Flexibility, Joint