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The anticlastogenic activity of sodium-copper-chlorophyllin was tested against two known clastogens, chromium(VI) oxide and the pesticide chlordane, both of which occur as environmental toxicants. The chemicals were administered to male Swiss albino mice by gavage and chromosomes were studied from bone marrow cells 24 h after the exposure, following colchicine-air drying-Giemsa preparation. The end-points screened were the frequencies of chromosomal aberrations and damaged cells. The clastogenic effects induced by chromium in aqueous solution (20 mg/kg body weight) were reduced to a significant level by chlorophyllin (1.5 mg/kg body weight), when administered both before and simultaneously with the toxicant. The effects of chlordane in olive oil (10 mg/kg body weight) were, however, not reduced by the administration of chlorophyllin (1.5 and 3 mg/kg body weight).
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Mutation research,
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November 1988,
Mutation research,
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Toxicology letters,
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January 1986,
Mutation research,
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G Talukder
April 1982,
Mutation research,
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Environmental and molecular mutagenesis,
D Sarkar, and
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G Talukder
April 1990,
Biological trace element research,
