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The L5178Y mouse lymphoma assay was used to examine the potential mutagenicity of three halogenated pyridine compounds. Position effects of the halogen moiety and the role of metabolic activation were analyzed based on induced mutant frequency, gross chromosome aberrations, and micronuclei. Without activation, 2-chloropyridine, 3-chloropyridine, and 2-chloro-5-trifluoromethylpyridine produced a small increase in mutant frequency; only the 2-chloropyridine activity was significantly increased with activation. All three compounds were also clastogenic as demonstrated by increases in chromosome aberrations and micronuclei (except for 2-chloro-5-trifluoromethylpyridine which did not induce micronuclei either with or without activation).
K L Dearfield, and
K Harrington-Brock, and
C L Doerr, and
L Parker, and
M M Moore
January 1999,
Environmental and molecular mutagenesis,
K L Dearfield, and
K Harrington-Brock, and
C L Doerr, and
L Parker, and
M M Moore
January 2001,
Environmental and molecular mutagenesis,
K L Dearfield, and
K Harrington-Brock, and
C L Doerr, and
L Parker, and
M M Moore
June 1986,
Mutation research,
K L Dearfield, and
K Harrington-Brock, and
C L Doerr, and
L Parker, and
M M Moore
May 1988,
Mutagenesis,
K L Dearfield, and
K Harrington-Brock, and
C L Doerr, and
L Parker, and
M M Moore
September 1987,
Mutation research,
K L Dearfield, and
K Harrington-Brock, and
C L Doerr, and
L Parker, and
M M Moore
January 2005,
Environmental and molecular mutagenesis,
K L Dearfield, and
K Harrington-Brock, and
C L Doerr, and
L Parker, and
M M Moore
May 2000,
Mutagenesis,
K L Dearfield, and
K Harrington-Brock, and
C L Doerr, and
L Parker, and
M M Moore
January 1990,
Environmental and molecular mutagenesis,
K L Dearfield, and
K Harrington-Brock, and
C L Doerr, and
L Parker, and
M M Moore
April 1978,
Mutation research,
K L Dearfield, and
K Harrington-Brock, and
C L Doerr, and
L Parker, and
M M Moore
November 1985,
Toxicology and industrial health,
