BIOMAT Database Logo BIOMAT Database Logo

Regional localization of the human vitronectin receptor alpha subunit gene (VNRA) to chromosome 2q31-->q32. 1993

E Fernández-Ruiz, and F Pardo-Manuel de Villena, and S Rodríguez de Córdoba, and F Sánchez-Madrid
Servicio de Immunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Spain.

The vitronectin receptor (av:beta 3; CD51/CD61), a member of the beta 3 integrin subfamily (cytoadhesins), functions as a receptor for a group of proteins that includes vitronectin, fibrinogen, thrombospondin, and von Willebrand factor. The human locus for the av gene (VNRA) was previously mapped to the long arm of chromosome 2 by DNA analysis of somatic cell hybrids. By using fluorescence in situ hybridization, coupled with GTG-banding, we have regionally mapped the human av gene to chromosome 2q31-->q32. An identical location was previously reported for the human gene coding for the integrin VLA-alpha 4 subunit (CD49D). These data, therefore, suggest the existence of a cluster of integrin genes at this chromosomal location.

UI MeSH Term Description Entries
D010980 Platelet Membrane Glycoproteins Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors. PM-GP,Platelet Glycoprotein,Platelet Membrane Glycoprotein,PM-GPs,Platelet Glycoproteins,Glycoprotein, Platelet,Glycoprotein, Platelet Membrane,Glycoproteins, Platelet,Glycoproteins, Platelet Membrane,Membrane Glycoprotein, Platelet,Membrane Glycoproteins, Platelet,PM GP
D002871 Chromosome Banding Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping. Banding, Chromosome,Bandings, Chromosome,Chromosome Bandings
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D002889 Chromosomes, Human, Pair 2 A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification. Chromosome 2
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005340 Fibrinogen Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products. Coagulation Factor I,Factor I,Blood Coagulation Factor I,gamma-Fibrinogen,Factor I, Coagulation,gamma Fibrinogen
D006023 Glycoproteins Conjugated protein-carbohydrate compounds including MUCINS; mucoid, and AMYLOID glycoproteins. C-Glycosylated Proteins,Glycosylated Protein,Glycosylated Proteins,N-Glycosylated Proteins,O-Glycosylated Proteins,Glycoprotein,Neoglycoproteins,Protein, Glycosylated,Proteins, C-Glycosylated,Proteins, Glycosylated,Proteins, N-Glycosylated,Proteins, O-Glycosylated
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014841 von Willebrand Factor A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor. Factor VIII-Related Antigen,Factor VIIIR-Ag,Factor VIIIR-RCo,Plasma Factor VIII Complex,Ristocetin Cofactor,Ristocetin-Willebrand Factor,von Willebrand Protein,Factor VIII Related Antigen,Factor VIIIR Ag,Factor VIIIR RCo,Ristocetin Willebrand Factor
D016023 Integrins A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. Integrin

Related Publications

E Fernández-Ruiz, and F Pardo-Manuel de Villena, and S Rodríguez de Córdoba, and F Sánchez-Madrid
Cloning and expression of human nebulin cDNAs and assignment of the gene to chromosome 2q31-q32.
April 1988, Genomics,
E Fernández-Ruiz, and F Pardo-Manuel de Villena, and S Rodríguez de Córdoba, and F Sánchez-Madrid
Assignment of the fucosidase pseudogene FUCA1P to chromosome region 2q31----q32.
January 1991, Cytogenetics and cell genetics,
E Fernández-Ruiz, and F Pardo-Manuel de Villena, and S Rodríguez de Córdoba, and F Sánchez-Madrid
Familial primary pulmonary hypertension locus mapped to chromosome 2q31-q32.
July 1998, Chest,
E Fernández-Ruiz, and F Pardo-Manuel de Villena, and S Rodríguez de Córdoba, and F Sánchez-Madrid
The gene for the alpha 4 subunit of the VLA-4 integrin maps to chromosome 2Q31-32.
November 1991, Blood,
E Fernández-Ruiz, and F Pardo-Manuel de Villena, and S Rodríguez de Córdoba, and F Sánchez-Madrid
Localization of a gene for Duane retraction syndrome to chromosome 2q31.
December 1999, American journal of human genetics,
E Fernández-Ruiz, and F Pardo-Manuel de Villena, and S Rodríguez de Córdoba, and F Sánchez-Madrid
Localization of the acetylcholine receptor gamma subunit gene to human chromosome 2q32----qter.
January 1989, Cytogenetics and cell genetics,
E Fernández-Ruiz, and F Pardo-Manuel de Villena, and S Rodríguez de Córdoba, and F Sánchez-Madrid
Localization of the human aryl hydrocarbon hydroxylase gene to the 2q31----2pter region of chromosome 2.
July 1985, Annals of human genetics,
E Fernández-Ruiz, and F Pardo-Manuel de Villena, and S Rodríguez de Córdoba, and F Sánchez-Madrid
Mapping of familial primary pulmonary hypertension locus (PPH1) to chromosome 2q31-q32.
June 1997, Circulation,
E Fernández-Ruiz, and F Pardo-Manuel de Villena, and S Rodríguez de Córdoba, and F Sánchez-Madrid
Localization of the gene encoding the alpha 2 subunit of the human VLA-2 receptor to chromosome 5q23-31.
September 1991, Somatic cell and molecular genetics,
E Fernández-Ruiz, and F Pardo-Manuel de Villena, and S Rodríguez de Córdoba, and F Sánchez-Madrid
Localization of the glycine receptor alpha 1 subunit gene (GLRA1) to chromosome 5q32 by FISH.
July 1994, Genomics,
Copied contents to your clipboard!