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Serial passage of Ross River virus in chick embryo fibroblasts selected for virus variants altered in their reactions to neutralizing monoclonal antibodies. The E1 and E2 genes of each antigenic variant were sequenced; single nucleotide changes were found in E2 leading to amino acid substitutions at either residue 4 (Glu-->Lys) or 218 (Asn-->Lys); no changes were found in the E1 gene. Variants with the substitution at E2 residue 218 replicated less efficiently in 1-day-old mice than did the parental strain. The variant changed at E2 residue 4 showed little alteration in replication efficiency in mice. Similar genotypic or phenotypic changes were not found in virus passaged serially in human or mosquito cell lines.
P J Kerr, and
R C Weir, and
L Dalgarno
October 1989,
Virology,
P J Kerr, and
R C Weir, and
L Dalgarno
August 1985,
The Australian journal of experimental biology and medical science,
P J Kerr, and
R C Weir, and
L Dalgarno
January 1981,
Biochemical and biophysical research communications,
P J Kerr, and
R C Weir, and
L Dalgarno
January 2003,
New South Wales public health bulletin,
P J Kerr, and
R C Weir, and
L Dalgarno
August 1986,
Virus research,
P J Kerr, and
R C Weir, and
L Dalgarno
January 1960,
Studii si cercetari de inframicrobiologie,
P J Kerr, and
R C Weir, and
L Dalgarno
December 1988,
Virology,
P J Kerr, and
R C Weir, and
L Dalgarno
November 1966,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
P J Kerr, and
R C Weir, and
L Dalgarno
July 1974,
Cancer research,
P J Kerr, and
R C Weir, and
L Dalgarno
December 1977,
Virology,
