-transparent.png){kind=logo}
The effect of the ophthalmic solution of tranilast, an anti-allergic agent, on allergic conjunctivitis was studied in passively sensitized guinea pigs. We determined the content of uranine dye and histamine in tears and histopathologically examined palpebral conjunctiva. After instillation of antigen into the conjunctival sac, inflammation of the palpebral conjunctiva, an increase in leaked dye and the release of histamine were found. In the histopathological study, tranilast (1.0%) suppressed the appearance of edema and infiltration of inflammatory cells. Tranilast suppressed the leakage of uranine in a dose-dependent manner. A 0.5% solution of diphenhydramine also showed the inhibitory effect on the leakage of uranine. The inhibitory effect of 0.5% tranilast on antigen-induced dye leakage and histamine release lasted for 6 hr. These results suggest that topically applied tranilast is effective for allergic conjunctivitis.
F Itoh, and
Y Komatsu, and
F Taya, and
M Isaji, and
M Kojima, and
Y Momose, and
H Suzawa, and
H Miyata, and
T Shibazaki
August 1991,
Journal of pharmacobio-dynamics,
F Itoh, and
Y Komatsu, and
F Taya, and
M Isaji, and
M Kojima, and
Y Momose, and
H Suzawa, and
H Miyata, and
T Shibazaki
June 1991,
Journal of pharmacobio-dynamics,
F Itoh, and
Y Komatsu, and
F Taya, and
M Isaji, and
M Kojima, and
Y Momose, and
H Suzawa, and
H Miyata, and
T Shibazaki
August 2013,
Experimental eye research,
F Itoh, and
Y Komatsu, and
F Taya, and
M Isaji, and
M Kojima, and
Y Momose, and
H Suzawa, and
H Miyata, and
T Shibazaki
April 2005,
Chinese medical journal,
F Itoh, and
Y Komatsu, and
F Taya, and
M Isaji, and
M Kojima, and
Y Momose, and
H Suzawa, and
H Miyata, and
T Shibazaki
August 2017,
Expert opinion on pharmacotherapy,
F Itoh, and
Y Komatsu, and
F Taya, and
M Isaji, and
M Kojima, and
Y Momose, and
H Suzawa, and
H Miyata, and
T Shibazaki
January 2014,
Clinical ophthalmology (Auckland, N.Z.),
F Itoh, and
Y Komatsu, and
F Taya, and
M Isaji, and
M Kojima, and
Y Momose, and
H Suzawa, and
H Miyata, and
T Shibazaki
February 1983,
American journal of ophthalmology,
F Itoh, and
Y Komatsu, and
F Taya, and
M Isaji, and
M Kojima, and
Y Momose, and
H Suzawa, and
H Miyata, and
T Shibazaki
November 1997,
Methods and findings in experimental and clinical pharmacology,
F Itoh, and
Y Komatsu, and
F Taya, and
M Isaji, and
M Kojima, and
Y Momose, and
H Suzawa, and
H Miyata, and
T Shibazaki
December 2003,
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics,
F Itoh, and
Y Komatsu, and
F Taya, and
M Isaji, and
M Kojima, and
Y Momose, and
H Suzawa, and
H Miyata, and
T Shibazaki
January 2022,
Journal of pharmacological and toxicological methods,
