Biomaterial Database

Effect of conditioned fear stress on serotonin metabolism in the rat brain. 1993

T Inoue, and T Koyama, and I Yamashita

Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo, Japan.

The effects of electric foot-shock stress (EFS) and conditioned fear stress (CFS) on serotonin [5-hydroxytryptamine (5-HT)] metabolism in seven various brain regions of the rat were studied by measuring tryptophan, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA). EFS for 30 min increased tryptophan levels in almost all brain regions but did not change 5-HT levels in any regions. It increased 5-HIAA levels in the medial prefrontal cortex (mPFC), nucleus accumbens, and amygdala. CFS (exposure to an environment paired previously with foot-shock) increased defecation and induced freezing behavior. It failed to change tryptophan and 5-HT levels in any brain regions but increased 5-HIAA level only in the mPFC. In contrast to EFS, which increased 5-HT metabolism in several other brain regions, increased metabolism of 5-HT was especially marked in the mPFC after CFS, regarded as psychological stress.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D003214	Conditioning, Classical	Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.	Reflex, Conditioned,Classical Conditioning,Classical Conditionings,Conditioned Reflex,Conditionings, Classical
D003672	Defecation	The normal process of elimination of fecal material from the RECTUM.	Bowel Function,Bowel Movement,Bowel Functions,Bowel Movements,Defecations
D004597	Electroshock	Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states.	Electroconvulsive Shock,Electroconvulsive Shocks,Electroshocks,Shock, Electroconvulsive,Shocks, Electroconvulsive
D005239	Fear	The affective response to an actual current external danger which subsides with the elimination of the threatening condition.	Threat Cues,Threat Sensitivity,Cue, Threat,Fears,Sensitivity, Threat,Threat Cue,Threat Sensitivities
D006897	Hydroxyindoleacetic Acid		5-HIAA,5-Hydroxy-3-Indoleacetic Acid,5-Hydroxyindolamine Acetic Acid,5 Hydroxy 3 Indoleacetic Acid,5 Hydroxyindolamine Acetic Acid,Acetic Acid, 5-Hydroxyindolamine,Acid, 5-Hydroxy-3-Indoleacetic,Acid, 5-Hydroxyindolamine Acetic,Acid, Hydroxyindoleacetic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012701	Serotonin	A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.	5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine