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Protein synthesis was analysed in leukaemic cells from 10 chronic lymphocytic leukaemia (CLL) patients by 2D-gel electrophoresis of 14C-labelled proteins. There appeared to be only minor differences between each of the CLL samples, but there was evidence that the level of expression of a few of the proteins might have correlated to the stage of the disease. Comparison of the CLL samples to populations of normal B-lymphocytes demonstrated marked differences in protein synthesis between the leukaemic and non-malignant cells. We subsequently used the fluorescence activated cell sorter (FACs) to separate CD5+ from CD5- B-lymphocytes, but observed that the protein synthesis exhibited by these two populations was essentially the same, and both were very different to that observed in CLL cells. The significance of these observations with respect to the origins of CLL is discussed.
F K Saunders, and
R M Sharrard, and
D A Winfield, and
J Lawry, and
J R Goepel, and
B W Hancock, and
M H Goyns
February 1982,
The Journal of experimental medicine,
F K Saunders, and
R M Sharrard, and
D A Winfield, and
J Lawry, and
J R Goepel, and
B W Hancock, and
M H Goyns
January 1992,
Acta haematologica Polonica,
F K Saunders, and
R M Sharrard, and
D A Winfield, and
J Lawry, and
J R Goepel, and
B W Hancock, and
M H Goyns
January 1975,
Journal of the National Cancer Institute,
F K Saunders, and
R M Sharrard, and
D A Winfield, and
J Lawry, and
J R Goepel, and
B W Hancock, and
M H Goyns
February 2022,
Hematological oncology,
F K Saunders, and
R M Sharrard, and
D A Winfield, and
J Lawry, and
J R Goepel, and
B W Hancock, and
M H Goyns
April 1973,
The New England journal of medicine,
F K Saunders, and
R M Sharrard, and
D A Winfield, and
J Lawry, and
J R Goepel, and
B W Hancock, and
M H Goyns
March 1977,
Cancer research,
F K Saunders, and
R M Sharrard, and
D A Winfield, and
J Lawry, and
J R Goepel, and
B W Hancock, and
M H Goyns
January 2016,
Current topics in microbiology and immunology,
F K Saunders, and
R M Sharrard, and
D A Winfield, and
J Lawry, and
J R Goepel, and
B W Hancock, and
M H Goyns
October 1992,
Blood,
F K Saunders, and
R M Sharrard, and
D A Winfield, and
J Lawry, and
J R Goepel, and
B W Hancock, and
M H Goyns
August 1976,
The New England journal of medicine,
F K Saunders, and
R M Sharrard, and
D A Winfield, and
J Lawry, and
J R Goepel, and
B W Hancock, and
M H Goyns
July 1989,
American journal of hematology,
