-transparent.png){kind=logo}
The etiology of acute post-transfusion hepatitis (PTH) non-A, non-B (NANB) in China was investigated with the combination of advanced techniques, including a second generation of enzyme immunoassay for detection of the antibodies to hepatitis C virus (anti-HCV), a reverse transcription and nested polymerase chain reaction (RT-nPCR) for HCV RNA, and a PCR for hepatitis B virus DNA. Of the 57 patients who were diagnosed as acute PTH-NANB, 46 (80.7%) were positive for anti-HCV and 41 (71.9%) had HCV RNA. Combining together, 53 (93.0%) were seropositive for anti-HCV and/or HCV RNA. Surprisingly, 18 of these with HCV markers were also positive for HBV DNA, although they were negative for HBsAg, suggesting that a portion of the patients with acute PTH NANB were coinfected by both HCV and HBV. In addition, 4 (7%) of the patients with acute PTH-NANB had no detectable HCV and HBV markers with the use of the above-mentioned techniques. These results indicate that etiologic agents(s) other than HCV and HBV may also cause acute PTH-NANB or that the current techniques may still not be sensitive enough to detect trace levels of HCV and HBV markers.
K X Luo, and
Z S Liang, and
S C Yang, and
R Zhou, and
Q H Meng, and
Y W Zhu, and
H T He, and
S Jiang
December 1988,
Nihon rinsho. Japanese journal of clinical medicine,
K X Luo, and
Z S Liang, and
S C Yang, and
R Zhou, and
Q H Meng, and
Y W Zhu, and
H T He, and
S Jiang
June 1991,
Liver,
K X Luo, and
Z S Liang, and
S C Yang, and
R Zhou, and
Q H Meng, and
Y W Zhu, and
H T He, and
S Jiang
March 1977,
Lancet (London, England),
K X Luo, and
Z S Liang, and
S C Yang, and
R Zhou, and
Q H Meng, and
Y W Zhu, and
H T He, and
S Jiang
June 1987,
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
K X Luo, and
Z S Liang, and
S C Yang, and
R Zhou, and
Q H Meng, and
Y W Zhu, and
H T He, and
S Jiang
June 1982,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
K X Luo, and
Z S Liang, and
S C Yang, and
R Zhou, and
Q H Meng, and
Y W Zhu, and
H T He, and
S Jiang
September 1984,
Orvosi hetilap,
K X Luo, and
Z S Liang, and
S C Yang, and
R Zhou, and
Q H Meng, and
Y W Zhu, and
H T He, and
S Jiang
October 1978,
Lancet (London, England),
K X Luo, and
Z S Liang, and
S C Yang, and
R Zhou, and
Q H Meng, and
Y W Zhu, and
H T He, and
S Jiang
September 1980,
Bollettino dell'Istituto sieroterapico milanese,
K X Luo, and
Z S Liang, and
S C Yang, and
R Zhou, and
Q H Meng, and
Y W Zhu, and
H T He, and
S Jiang
October 1988,
Revue francaise de transfusion et immuno-hematologie,
K X Luo, and
Z S Liang, and
S C Yang, and
R Zhou, and
Q H Meng, and
Y W Zhu, and
H T He, and
S Jiang
December 1975,
Gastroenterology,
