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Sex steroids are thought to play an essential role in the pathogenesis of human benign prostatic hyperplasia (BPH). Since recent studies in animal models and in men have shown that estrogens might be causally linked to the onset and maintenance of BPH, we examined the effect of 1-methyl-androsta-1,4-diene-3,17-dione (Atamestane), a newly developed aromatase inhibitor, in men with BPH. In an open multicenter study 49 men (mean age 70.1 years, range 55 to 84) with obstructive BPH were treated with atamestane (3 x 200 mg/day) for 3 months. Of the 49 patients 44 completed the treatment period; the other patients discontinued the study for reasons unrelated to treatment. With treatment BPH-related symptoms such as daytime voiding frequency, nycturia, peak flow and residual urine improved considerably; however, these parameters did not reach statistical significance. The mean prostatic volume decreased significantly from 74.2 +/- 31.7 to 64.0 +/- 31 ml (mean +/- SD). Serum estrogen levels decreased markedly during treatment. In addition intraprostatic estrogen concentration decreased with treatment as compared to estrogen levels in hyperplastic prostates from untreated patients. The following conclusions can be drawn from this study: first, estrogens appear to have an important supportive role in established BPH, and second, estrogen deprivation improved BPH-related symptoms and reduced significantly prostatic volume.
H U Schweikert, and
U W Tunn, and
U F Habenicht, and
J Arnold, and
T Senge, and
H Schulze, and
F H Schröder, and
J H Blom, and
O Ennemoser, and
W Horniger
July 1983,
The Journal of urology,
H U Schweikert, and
U W Tunn, and
U F Habenicht, and
J Arnold, and
T Senge, and
H Schulze, and
F H Schröder, and
J H Blom, and
O Ennemoser, and
W Horniger
January 2002,
Zhonghua nan ke xue = National journal of andrology,
H U Schweikert, and
U W Tunn, and
U F Habenicht, and
J Arnold, and
T Senge, and
H Schulze, and
F H Schröder, and
J H Blom, and
O Ennemoser, and
W Horniger
January 1993,
Verhandlungen der Deutschen Gesellschaft fur Pathologie,
H U Schweikert, and
U W Tunn, and
U F Habenicht, and
J Arnold, and
T Senge, and
H Schulze, and
F H Schröder, and
J H Blom, and
O Ennemoser, and
W Horniger
March 1965,
Archives of pathology,
H U Schweikert, and
U W Tunn, and
U F Habenicht, and
J Arnold, and
T Senge, and
H Schulze, and
F H Schröder, and
J H Blom, and
O Ennemoser, and
W Horniger
January 1986,
The Prostate,
H U Schweikert, and
U W Tunn, and
U F Habenicht, and
J Arnold, and
T Senge, and
H Schulze, and
F H Schröder, and
J H Blom, and
O Ennemoser, and
W Horniger
January 1989,
The Journal of urology,
H U Schweikert, and
U W Tunn, and
U F Habenicht, and
J Arnold, and
T Senge, and
H Schulze, and
F H Schröder, and
J H Blom, and
O Ennemoser, and
W Horniger
August 1999,
Scandinavian journal of urology and nephrology,
H U Schweikert, and
U W Tunn, and
U F Habenicht, and
J Arnold, and
T Senge, and
H Schulze, and
F H Schröder, and
J H Blom, and
O Ennemoser, and
W Horniger
January 1982,
The Prostate,
H U Schweikert, and
U W Tunn, and
U F Habenicht, and
J Arnold, and
T Senge, and
H Schulze, and
F H Schröder, and
J H Blom, and
O Ennemoser, and
W Horniger
April 2004,
Rinsho byori. The Japanese journal of clinical pathology,
H U Schweikert, and
U W Tunn, and
U F Habenicht, and
J Arnold, and
T Senge, and
H Schulze, and
F H Schröder, and
J H Blom, and
O Ennemoser, and
W Horniger
January 1984,
Progress in clinical and biological research,
