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Data obtained using the mouse-preimplantation-embryo-chimera assay are presented that show a transmitted effect following low-dose irradiation of immature oocytes in vivo. Six-week-old female mice were irradiated using 137Cs-gamma-rays (0.05 Gy, 0.15 Gy, and unexposed controls). At 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, and 12 weeks post exposure, the mice were mated and aggregation chimeras made from the 4-cell embryos. Three independent experiments have now been carried out, all showing a significant embryonic cell-proliferation disadvantage of the embryos obtained from the females treated 7 weeks previously, i.e., embryos from oocytes that were immature at the time of radiation exposure. No effect was detected at 1-6 weeks when embryos were obtained from maturing oocytes. Also, the effect was not seen at 8, 9, 10, 11, and 12 weeks post exposure. The implications of these results are discussed in the light of previous studies on mouse oocytes.
T Straume, and
O G Raabe, and
K J Walsh, and
L M Wiley
September 1976,
Transplantation proceedings,
T Straume, and
O G Raabe, and
K J Walsh, and
L M Wiley
February 1988,
Radiation research,
T Straume, and
O G Raabe, and
K J Walsh, and
L M Wiley
February 2002,
Current protocols in toxicology,
T Straume, and
O G Raabe, and
K J Walsh, and
L M Wiley
August 1987,
Development, growth & differentiation,
T Straume, and
O G Raabe, and
K J Walsh, and
L M Wiley
July 1990,
Development (Cambridge, England),
T Straume, and
O G Raabe, and
K J Walsh, and
L M Wiley
September 1994,
Human reproduction (Oxford, England),
T Straume, and
O G Raabe, and
K J Walsh, and
L M Wiley
August 1959,
Project report. USAF School of Aviation Medicine,
T Straume, and
O G Raabe, and
K J Walsh, and
L M Wiley
September 1959,
Journal of the National Cancer Institute,
T Straume, and
O G Raabe, and
K J Walsh, and
L M Wiley
October 1993,
Biology of reproduction,
T Straume, and
O G Raabe, and
K J Walsh, and
L M Wiley
June 1987,
Development, growth & differentiation,
