-transparent.png){kind=logo}
We examined effects of deregulated c-fos on the proliferation and differentiation of B cells in vitro, using splenic B cells from H2-c-fos transgenic mice. When these cells were cultured with lipopolysaccharide (LPS) plus recombinant interleukin 4 (rIL-4) (10(4) U/ml), the proliferative response of the B cells was augmented with any dose of LPS used. This augmented proliferation resulted in an increase in IgG1 production in the culture, at the lower concentrations of LPS (< 2.5 micrograms/ml). However, H2-c-fos B cells did not produce IgG1 in the culture at higher concentrations of LPS (> 5 micrograms/ml) probably due to the perturbation of B cell differentiation to antibody-forming cells. These results suggest that the deregulated expression of c-fos modulates the proliferation and differentiation of B cells stimulated with LPS plus rIL-4.
T Koizumi, and
Y Ochi, and
S Imoto, and
N Sakai, and
S Takao, and
S Kobayashi, and
M Matsuoka, and
H Sakano, and
U Rüther, and
T Tokuhisa
July 1993,
Immunobiology,
T Koizumi, and
Y Ochi, and
S Imoto, and
N Sakai, and
S Takao, and
S Kobayashi, and
M Matsuoka, and
H Sakano, and
U Rüther, and
T Tokuhisa
February 1993,
Cancer letters,
T Koizumi, and
Y Ochi, and
S Imoto, and
N Sakai, and
S Takao, and
S Kobayashi, and
M Matsuoka, and
H Sakano, and
U Rüther, and
T Tokuhisa
August 1995,
Immunobiology,
T Koizumi, and
Y Ochi, and
S Imoto, and
N Sakai, and
S Takao, and
S Kobayashi, and
M Matsuoka, and
H Sakano, and
U Rüther, and
T Tokuhisa
June 1995,
Cancer letters,
T Koizumi, and
Y Ochi, and
S Imoto, and
N Sakai, and
S Takao, and
S Kobayashi, and
M Matsuoka, and
H Sakano, and
U Rüther, and
T Tokuhisa
February 2010,
The Journal of biological chemistry,
T Koizumi, and
Y Ochi, and
S Imoto, and
N Sakai, and
S Takao, and
S Kobayashi, and
M Matsuoka, and
H Sakano, and
U Rüther, and
T Tokuhisa
January 1988,
Cold Spring Harbor symposia on quantitative biology,
T Koizumi, and
Y Ochi, and
S Imoto, and
N Sakai, and
S Takao, and
S Kobayashi, and
M Matsuoka, and
H Sakano, and
U Rüther, and
T Tokuhisa
October 1995,
The Kobe journal of medical sciences,
T Koizumi, and
Y Ochi, and
S Imoto, and
N Sakai, and
S Takao, and
S Kobayashi, and
M Matsuoka, and
H Sakano, and
U Rüther, and
T Tokuhisa
February 2017,
Science (New York, N.Y.),
T Koizumi, and
Y Ochi, and
S Imoto, and
N Sakai, and
S Takao, and
S Kobayashi, and
M Matsuoka, and
H Sakano, and
U Rüther, and
T Tokuhisa
January 1987,
Nature,
T Koizumi, and
Y Ochi, and
S Imoto, and
N Sakai, and
S Takao, and
S Kobayashi, and
M Matsuoka, and
H Sakano, and
U Rüther, and
T Tokuhisa
February 2003,
The Journal of biological chemistry,
